1 Result for "

Contragestazol

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Contragestazol" in MCE Product Catalog:

Cat. No.: HY-182447
CAS No.: 69095-83-6
Synonyms: DL111-IT
Target:  

CDK Apoptosis

Research Areas:  

Endocrinology Cancer

Contragestazol (DL111-IT) is a non-hormonal antifertility agent. Contragestazol reduces the expression of Cyclin D1 and CDK4, increases the expression of total retinoblastoma protein (pRb), and decreases the level of hyperphosphorylated pRb. Contragestazol induces G0/G1 phase cell cycle arrest. Contragestazol inhibits embryonic development by inducing luteal cell apoptosis and reducing intrauterine polyamine levels. Contragestazol exhibits antitumor activity against prostate cancer, S180 tumor and H22 tumor. Contragestazol shows extremely potent activity in terminating early pregnancy in animals .
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