3 Results for "

D228

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "D228" in MCE Product Catalog:

Cat. No.: HY-164670
CAS No.: 2676188-98-8
Target:  

p38 MAPK MyD88

Research Areas:  

Inflammation/Immunology

D228 is an orally active antiinflammatory agent. D228 reduces ConA induced T lymphocyte cell proliferation (IC50: 42.85 μM) and LPS induced B lymphocyte cell proliferation (IC50: 3.15 μM). D228 is effective against inflammatory bowel disease (IBD). D228 alleviates the DSS (HY-116282C)-induced inflammation response in the IBD model by downregulating the MyD88/TRAF6/p38 signaling .
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Cat. No.: HY-15149S2
Synonyms: FK 228-d7; FR 901228-d7; NSC 630176-d7
Romidepsin-d7 (FK 228-d7) is deuterium labeled Romidepsin. Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively . Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis .
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Cat. No.: HY-157148
CAS No.: 2925447-16-9
Target:  

c-Met/HGFR Trk Receptor

Research Areas:  

Cancer

1D228 is a c-Met/TRK inhibitor with antitumor activity. 1D228 inhibits cyclin D1 to induce G0/G1 arrest and inhibit cancer cell proliferation and migration. 1D228 can be used in the study of gastric, liver and vascular tumors .
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