1 Result for "

DI591

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "DI591" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-124602
CAS No.: 2245887-38-9
Purity:  99.42%
Target:  

E1/E2/E3 Enzyme

Research Areas:  

Cancer

DI-591 is a potent, high-affinity and cell-permeable inhibitor of the DCN1-UBC12 interaction. DI-591 binds to DCN1 and DCN2 with Ki values of 12 nM and 10.4 nM, respectively and has no appreciable binding to DCN3, DCN4, and DCN5 proteins. DI-591 selectively inhibits neddylation of cullin 3 but has no or minimal effect on neddylation of other cullin family members .
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