4 Results for "

ECD2

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "ECD2" in MCE Product Catalog:

1
Zanidatamab
Zanidatamab
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1 Cited Publications
Cat. No.: HY-P99380
CAS No.: 2169946-15-8
Synonyms: ZW 25; ZW-49 Antibody

Target:  

EGFR

Research Areas:  

Cancer

Zanidatamab (ZW25) is a humanised, bispecific monoclonal antibody targeting 2 distinct HER2 epitopes (ECD2 and ECD4). Zanidatamab has anti-tumour activity .
Sudubrilimab
Sudubrilimab
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Cat. No.: HY-P99963
CAS No.: 2387417-06-1
Synonyms: HS636

Target:  

PD-1/PD-L1

Research Areas:  

Cancer

Sudubrilimab (HS636) is an Ig G1-kappa monoclonal antibody against PDL1. Sudubrilimab is fused at the C terminus of the heavy chain to a TGF-β1 receptor Ⅱ ectodomain (TGFBR2-ECD), and which can sequester the PD-1/PD-L1 pathway and TGF-β bioactivity in the immunosuppressive tumor microenvironment .
TQB2102
TQB2102
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Cat. No.: HY-185816
Target:  

Antibody-Drug Conjugates (ADCs) EGFR Topoisomerase DNA/RNA Synthesis

Research Areas:  

Cancer

TQB2102 is a bispecific epitope antibody-drug conjugate targeting HER2, composed of the antibody Rolditamig (HY-P992130) and the toxin molecule Deruxtecan-d2 (HY-13631ES3). TQB2102 binds to the ECD2 and ECD4 domains of HER2, promotes its own internalization by HER2-expressing cells, and delivers deuterated DXd payload to inhibit topoisomerase I. TQB2102 induces antibody-dependent cellular cytotoxicity, DNA damage, bystander killing activity, and inhibits cancer cell proliferation. TQB2102 can be used in research related to various cancers including metastatic breast cancer, colorectal cancer, and gastric/gastroesophageal junction adenocarcinoma [2].
NM-02
NM-02
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Cat. No.: HY-P991239

Target:  

EGFR

Research Areas:  

Cancer

NM-02 is an antibody targeting HER2 with an EC50 value of 1.2 nM. NM-02 binds to domains I and II of HER2-ECD, blocking HER2-related signaling pathways. NM-02 is promising for research of HER2-positive breast cancer .
Assay Types