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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
EN6
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "EN6" in MCE Product Catalog:
5
5 Cited Publications
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EN6 is a small-molecule in vivo autophagy activator that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase. EN6-mediated modification of ATP6V1A uncouples v-ATPase from Rag, leading to inhibition of mTORC1 signalling, increased lysosomal acidification, and activation of autophagy. EN6 also scavenges TDP-43 aggregates (causative agents of frontotemporal dementia) in a lysosome-dependent manner .
Cat. No.: HY-N8134
CAS No.: 1809980-25-3
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Cat. No.: HY-N9091
CAS No.: 127681-58-7
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Cat. No.: HY-N9078
CAS No.: 192566-65-7
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Cat. No.: HY-N9306
CAS No.: 74635-87-3
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Cat. No.: HY-N17087
CAS No.: 61570-81-8
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Cat. No.: HY-N2705
CAS No.: 36450-02-9
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Cat. No.: HY-N16903
CAS No.: 2193060-24-9
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
