1 Result for "

Edralbrutinib

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "Edralbrutinib" in MCE Product Catalog:

製品番号: HY-137438
CAS 番号: 1858206-58-2
純度:  99.75%
別名: TG-1701
Target:  

Btk

研究分野:  

Cancer

Edralbrutinib (TG-1701) is a highly selective, orally available irreversible BTK inhibitor, with an EC50 of 6.70 nM and a Kd of 3 nM against human BTK. Edralbrutinib inhibits downstream signaling of the B cell receptor, induces dephosphorylation of Ikaros Ser442/445, promotes nuclear exclusion of Ikaros, attenuates Ikaros gene signatures, and exerts anti-tumor activity. Edralbrutinib can be used in research related to B-cell non-Hodgkin lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma .
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