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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
FAS-II pathway
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "FAS-II pathway" in MCE Product Catalog:
Cat. No.: HY-187335
Target:
Domaines de recherche:
HadAB/InhA=IN-1 is a dual inhibitor of Mycobacterium tuberculosis InhA and HadAB with an InhA IC50 of 0.81 μM. HadAB/InhA=IN-1 inhibits InhA enzymatic activity in the FAS-II pathway of mycolic acid biosynthesis. HadAB/InhA=IN-1 undergoes EthA-mediated activation to covalently bind HadA and inhibit HadAB dehydratase function in the same FAS-II pathway. HadAB/InhA=IN-1 reduces mycolic acid-containing lipid and mycolic acid production, and accumulates standard fatty acids in Mycobacterium tuberculosis. HadAB/InhA=IN-1 exhibits antimycobacterial activity against drug-susceptible, ethA-deficient, and multi-drug-resistant Mycobacterium tuberculosis isolates. HadAB/InhA=IN-1 shows cytotoxic effects against human cancer and immortalized normal lung fibroblast cells. HadAB/InhA=IN-1 can be used for the research of tuberculosis .
Cat. No.: HY-186235
Target:
Domaines de recherche:
3-Hydroxydecanoyl-NAC is a substrate mimetic of the bacterial fatty acid biosynthetic pathway, and exhibits activity against FabA and FabG of Pseudomonas aeruginosa. 3-Hydroxydecanoyl-NAC acts as a stable mimetic of acyl carrier protein-linked fatty acids, which are key intermediates in the bacterial FASII pathway. 3-Hydroxydecanoyl-NAC serves as a substrate for Pseudomonas aeruginosa FabA, enabling the measurement of the dehydration activity of this enzyme .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
