2 Results for "

FLT3/PM

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "FLT3/PM" in MCE Product Catalog:

  • Targets Recommended:
Cat. No.: HY-132200
CAS No.: 2226789-82-6
Purity:  99.93%
Research Areas:  

Cancer

UNC5293 is a MERTK-selective and potent inhibitor (Ki=190 pM). UNC5293 inhibits MERTK (IC50=0.9 nM) and is more selective over Axl, Tyro3 and Flt3. UNC5293 exhibits excellent mouse PK properties and is used for bone marrow leukemia research .
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Cat. No.: HY-P991641
Synonyms: LY3012218

Target:  

FLT3 p38 MAPK STAT PI3K Akt

Research Areas:  

Cancer

IMC-EB10 (LY3012218) is an anti-FLT3 monoclonal antibody. IMC-EB10 binds to FLT3 with high affinity (Kd = 158 pM) and blocks the binding of FLT3 ligand to FLT3 (IC50 ≈ 10 nM), thereby inhibiting MAPK, STAT5, and PI3K/Akt signaling in leukemia cells. IMC-EB10 can enhance the anti-leukemic effect of Methotrexate (HY-14519) and inhibit leukemias expressing wild-type or ITD-mutated FLT3 receptors. IMC-EB10 prolongs the survival of acute lymphoblastic leukemia (ALL) cells and primary leukemia samples and reduces engraftment in non-obese diabetic/severe combined immunodeficiency patients. IMC-EB10 is indicated for leukemia research .
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