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Results for "

FOP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Anaplastic lymphoma kinase (ALK) (1) DNA/RNA Synthesis (1) RIP kinase (2) Small Interfering RNA (siRNA) (6) TGF-beta/Smad (1) TGF-β Receptor (7)
By Research Areas:	Cancer (3) Inflammation/Immunology (3) Metabolic Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (3) siRNAs (6)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99632

Garetosmab 1 Publications Verification REGN 2477	TGF-β Receptor	Inflammation/Immunology
Garetosmab (REGN 2477) is a fully human IgG4 monoclonal antibody that specifically inhibits activin A. Garetosmab can be used for fibrodysplasia ossificans progressiva (FOP) research .

HY-16712

LDN-214117 2 Publications Verification	TGF-β Receptor	Cancer
LDN-214117 is an orally active ALK2 inhibitor with well-tolerated and good brain penetration. LDN-214117 has a high selectivity and low cytotoxicity for ALK2 with an IC₅₀ value of 24 nM. LDN-214117 also is a specific bone morphogenetic proteins (BMPs) signaling inhibitor and has relatively selective inhibition for BMP6 with an IC₅₀ value of 100 nM. LDN-214117 can be used for the research of fibrodysplasia ossificans progressiva (FOP), diffuse intrinsic pontine glioma (DIPG) .

HY-15897

LDN-212854 1 Publications Verification	TGF-β Receptor	Cancer
LDN-212854 is a bone morphogenetic protein (BMP) inhibitor that potently inhibits ALK2 (IC₅₀: 1.3 nM). LDN-212854 also inhibits ALK1 (IC₅₀: 2.40 nM). LDN-212854 can be used in the research of fibrodysplasia ossificans progressive and cancers, such as hepatocellular carcinoma (HCC) .

HY-148234

M4K2234	Anaplastic lymphoma kinase (ALK) TGF-beta/Smad	Cancer
M4K2234, a chemical probe, is an orally active, highly selective inhibitor of ALK1 and ALK2 with IC₅₀ values of 7 nM and 14 nM, respectively. M4K2234 specifically blocks BMP signaling by inhibiting the phosphorylation of SMAD1/5/8. M4K2234 inhibits BMP7-stimulated reporter gene activity (IC₅₀ = 16 nM). M4K2234 can be used for the investigation of ALK1/2-mediated biological processes and related diseases such as diffuse midline glioma (DMG) and fibrodysplasia ossificans progressiva (FOP) .

HY-136773

KER047 ALK2-IN-4	TGF-β Receptor	Metabolic Disease
KER047 (ALK2-IN-4) is a potent activin receptor-like kinase-2 (ALK2) inhibitor. KER047 can be used for the research of metabolic disease, such as fibrodysplasia ossificans progressiva (FOP).

HY-19628

OD36	RIP kinase TGF-β Receptor	Inflammation/Immunology
OD36 is a RIPK2 inhibitor with an IC₅₀ of 5.3 nM. OD36 is a macrocyclic inhibitor with potent binding to the ALK2 kinase ATP pocket. OD36 shows ALK2-directed activity with K_Ds of 37 nM .

HY-19628A

OD36 hydrochloride	RIP kinase TGF-β Receptor	Inflammation/Immunology
OD36hydrochloride is a RIPK2 inhibitor with an IC₅₀ of 5.3 nM. OD36 hydrochloride is a macrocyclic inhibitor with potent binding to the ALK2 kinase ATP pocket. OD36 hydrochloride shows ALK2-directed activity with K_Ds of 37 nM .

HY-RS02515

CEP43 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CEP43 Human Pre-designed siRNA Set A contains three designed siRNAs for CEP43 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CEP43 Human Pre-designed siRNA Set A CEP43 Human Pre-designed siRNA Set A

HY-RS22441

Chtop Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Chtop Mouse Pre-designed siRNA Set A contains three designed siRNAs for Chtop gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Chtop Mouse Pre-designed siRNA Set A Chtop Mouse Pre-designed siRNA Set A

HY-136773A

KER047 succinate ALK2-IN-4 succinate	TGF-β Receptor	Metabolic Disease
KER047 succinate (ALK2-IN-4 succinate) is a potent activin receptor-like kinase-2 (ALK2) inhibitor. KER047 succinate can be used for the research of metabolic disease, such as fibrodysplasia ossificans progressiva (FOP).

HY-RS00236

ACVR1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ACVR1 Human Pre-designed siRNA Set A contains three designed siRNAs for ACVR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ACVR1 Human Pre-designed siRNA Set A ACVR1 Human Pre-designed siRNA Set A

HY-RS02697

CHTOP Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CHTOP Human Pre-designed siRNA Set A contains three designed siRNAs for CHTOP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CHTOP Human Pre-designed siRNA Set A CHTOP Human Pre-designed siRNA Set A

HY-145538

2'-Deoxyguanosine 5'-monophosphate disodium hydrate 5'-Deoxyguanylic acid disodium hydrate	DNA/RNA Synthesis	Others
2'-Deoxyguanosine 5'-monophosphate (5'-Deoxyguanylic acid; dGMP) disodium hydrate is an oxidizable target of the photosensitizer pterin (PT) and can be used to evaluate the photosensitizing properties of biopterins (such as Bip, Fop and Cap) . Pterin causes a photosensitive reaction of dGMP under UV-A radiation, causing damage to DNA molecules. There are two main mechanisms for the photosensitive oxidation of purine nucleotides by pterin in vitro: one is the hydrogen abstraction reaction of electron transfer from dGMP to the triplet excited state of pterin (type I mechanism), and the other is the interaction between dGMP and pterin. The reaction produces singlet molecular oxygen (1O2) (Type II mechanism) .

HY-RS28964

Chtop Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Chtop Rat Pre-designed siRNA Set A contains three designed siRNAs for Chtop gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Chtop Rat Pre-designed siRNA Set A Chtop Rat Pre-designed siRNA Set A

HY-RS20375

Cep43 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cep43 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cep43 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cep43 Mouse Pre-designed siRNA Set A Cep43 Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area	Image

HY-P99632

Garetosmab 1 Publications Verification REGN 2477	TGF-β Receptor	Inflammation/Immunology
Garetosmab (REGN 2477) is a fully human IgG4 monoclonal antibody that specifically inhibits activin A. Garetosmab can be used for fibrodysplasia ossificans progressiva (FOP) research .

Species:	Human (3)
Tag:	His (2) GST (1) Fc (2)
Source:	HEK293 (2) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P76927

	FGFR1OP Protein, Human (sf9, His-GST) Centrosomal protein 43; FGFR1 oncogene partner; CEP43; FOP	Human	Sf9 insect cells
	FGFR1OP is critical for microtubule dynamics, anchoring microtubules at centrosomes, which is critical for cell organization. It plays an integral role in cilia formation and helps control the complex process of cilia formation. FGFR1OP Protein, Human (sf9, His-GST) is the recombinant human-derived FGFR1OP protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P72769

	Activin RIA Protein, Human (HEK293, Fc) Receptor protein serine/threonine kinase; ACVR1; ACVR1A; FOP; SKR1; TSRI	Human	HEK293
	Activin A receptor, type I (ACVR1), also known as ALK-2, is a bone morphogenetic protein (BMP) type I receptor. ACVR1 is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. Activin RIA Protein, Human (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 102 amino acids (D23-V124).

HY-P72812

	Activin RIA Protein, Human (HEK293, His-Fc) Activin receptor type-1; ACTR-I; ALK-2; SKR1; TSR-I; ACVR1; ACVRLK2	Human	HEK293
	Activin A receptor, type I (ACVR1), also known as ALK-2, is a bone morphogenetic protein (BMP) type I receptor. ACVR1 is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. Activin RIA Protein, Human (HEK293, His-Fc) is produced in HEK293 cells with a C-Terminal His-tag and a C-Terminal Fc-tag . It consists of 124 amino acids (M1-V124).

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Host:	Mouse (2) Rabbit (4)
Reactivity:	Human (6) Rat (2) Mouse (4)
Application:	IHC-P (2) ICC/IF (3) IP (3) WB (4) FC (2) ELISA (2)
Isotype:	IgG (4) IgG1 (2)
Conjugation:	Non-conjugated (6)
Clonality:	Monoclonal (2) Monoclonal Antibody (1) Recombinant (2)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84482

	ACVR1 Antibody (YA4179) FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2	IHC-P, ICC/IF, FC, ELISA	Human
	ACVR1 Antibody (YA4179) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ACVR1.

HY-P84482A

	ACVR1 Antibody (YA4179)(PBS only) FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2	IHC-P, ICC/IF, FC, ELISA	Human
	ACVR1 Antibody (YA4179) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ACVR1.

HY-P83198

	Activin Receptor Type I Antibody (YA2943) ACTRI; Acvr1; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI	WB, IP	Human, Mouse, Rat
	Activin Receptor Type I Antibody (YA2943) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Activin Receptor Type I.

HY-P810798

	FOP Antibody (YA10041) FGFR1OP, FOP, CEP43, Centrosomal protein 43, FGFR1 oncogene partner	WB, ICC/IF	Human, Mouse, Rat
	FOP Antibody (YA10041) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to FOP.

HY-P82249

	Activin Receptor Type IA Antibody (YA1994) ACTRI; Acvr1; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI	WB, IP	Human, Mouse
	Activin Receptor Type IA Antibody (YA1994) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Activin Receptor Type IA.

HY-P82249A

	Activin Receptor Type IA Antibody (YA1994)(PBS only) ACTRI; Acvr1; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI	WB, IP	Human, Mouse
	Activin Receptor Type IA Antibody (YA1994) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Activin Receptor Type IA.