8 Results for "

GJ

" in MedChemExpress (MCE) Product Catalog:
Products (8)

8 Results for "GJ" in MCE Product Catalog:

5
5 Cited Publications
Cat. No.: HY-P1136
CAS No.: 1507930-57-5
Target:  

Gap Junction Protein

Research Areas:  

Cardiovascular Disease

Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial .
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5
5 Cited Publications
Cat. No.: HY-P1136A
Target:  

Gap Junction Protein

Research Areas:  

Cardiovascular Disease

Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial .
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1
1 Cited Publications
Cat. No.: HY-101203
CAS No.: 1459687-89-8
Target:  

Drug Derivative

Research Areas:  

Metabolic Disease Cancer

GJ103 is a read-through compound that can induce read through of premature stop codons. GJ103 has potential for the research of genetic disorders caused by nonsense mutations .
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1
1 Cited Publications
Cat. No.: HY-101203A
CAS No.: 1459687-96-7
Purity:  99.46%
Target:  

DNA/RNA Synthesis

Research Areas:  

Metabolic Disease Cancer

GJ103 sodium is a read-through compound that can induce read through of premature stop codons. GJ103 sodium has potential for the research of genetic disorders caused by nonsense mutations .
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1
1 Cited Publications
Cat. No.: HY-136835
CAS No.: 1216676-34-4
Purity:  99.74%
Target:  

ATM/ATR

Research Areas:  

Neurological Disease

GJ071 oxalate induces ATM kinase activity in ataxia telangiectasia (A-T) cells carrying homozygous TGA or TAG stop codons .
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Cat. No.: HY-174830
CAS No.: 3099808-68-8
Target:  

PD-1/PD-L1

Research Areas:  

Cancer

GJ19 is a PD-L1 inhibitor with an IC50 of 32.06 nM. GJ19 can effectively bind to human/murine PD-L1 protein with Kd values of 171 and 290 nM, respectively. GJ19 concentration-dependently promotes HepG2 cell mortality in a co-culture model of HepG2/hPD-L1 and Jurkat T/hPD-1 cells. GJ19 effectively suppresses tumor growth in a B16-F10 melanoma mouse model. GJ19 can be used for the study of tumor immunotherapy .
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Cat. No.: HY-126210
CAS No.: 943092-47-5
Research Areas:  

Others

GJ072 is a read-through compound (RTCs). GJ072 can induce “readthrough” .
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Cat. No.: HY-101203AR
CAS No.: 1459687-96-7
GJ103 (sodium) (Standard) is the analytical standard of GJ103 (sodium) (HY-101203A). This product is intended for research and analytical applications. GJ103 sodium is a read-through compound that can induce read through of premature stop codons. GJ103 sodium has potential for the research of genetic disorders caused by nonsense mutations .
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