Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
GKAs
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "GKAs" in MCE Product Catalog:
3
3 Cited Publications
Target:
Research Areas:
RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC50 of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes .
1
1 Cited Publications
Target:
Research Areas:
AM-2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with an EC50 of 60 nM.
Target:
Research Areas:
GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose). GKA50 stimulates insulin release from mouse islets of Langerhans. GKA50 is a glucose-like activator of beta-cell metabolism in rodent and human islets and a Ca 2+-dependent modulator of insulin secretion. GKA50 shows significant glucose lowering in high fat fed female rats .
Synonyms: PF-04937319
Target:
Research Areas:
Nerigliatin (PF-04937319) is a orally active glucokinase activator (GKA) with EC50 value of 154.4 μM. Nerigliatin maintains glucose-lowering efficacy. Nerigliatin causes peripheral nerve degeneration. Nerigliatin can be used in type 2 diabetes research.
Cat. No.: HY-116682
CAS No.: 863504-35-2
Target:
Research Areas:
GKA-71 is an orally active Glucokinase activator, possesses an islet protective effect .
Cat. No.: HY-15671A
Target:
Research Areas:
GKA50 quarterhydrate is a potent glucokinase activator (EC50=33 nM at 5 mM glucose) and stimulates insulin release from mouse islets of Langerhans. GKA50 quarterhydrate is a glucose-like activator of beta-cell metabolism in rodent and human islets and a Ca 2+-dependent modulator of insulin secretion. GKA50 quarterhydrate shows significant glucose lowering in high fat fed female rats .
Cat. No.: HY-108328R
CAS No.: 1245603-92-2
Synonyms: PF-04937319 (Standard)
Target:
Research Areas:
Nerigliatin (Standard) is the analytical standard of Nerigliatin. This product is intended for research and analytical applications. Nerigliatin (PF-04937319) is a orally active glucokinase activator (GKA) with EC50 value of 154.4 μM. Nerigliatin maintains glucose-lowering efficacy. Nerigliatin causes peripheral nerve degeneration. Nerigliatin can be used in type 2 diabetes research.
Cat. No.: HY-100221R
CAS No.: 1442684-77-6
Target:
Research Areas:
AM-2394 (Standard) is the analytical standard of AM-2394 (HY-100221). This product is intended for research and analytical applications. AM-2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with an EC50 of 60 nM.
Cat. No.: HY-10595R
CAS No.: 300353-13-3
Target:
Research Areas:
RO-28-1675 (Standard) is the analytical standard of RO-28-1675 (HY-10595). This product is intended for research and analytical applications. RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC50 of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
