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GP262

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-180261
    GP262

    		PROTACs mTOR PI3K Apoptosis Cancer
    GP262 is a PI3K/mTOR PROTAC degrader targeting PI3Kγ, PI3Kα and mTOR with DC50 values of 42.23 nM, 227.4 nM and 45.4 nM, respectively in MDA-MB-231 cells. GP262 induces degradation of p110α and p110γ with a DC50 of 227.4 and 42.23 nM. GP262 efficient modulates the PI3K/AKT/mTOR pathway, achieving degradation through the ubiquitin-proteasome system (UPS). GP262 also exhibits robust antiproliferative activity and induces apoptosis in vitro. GP262 exhibits tumor growth suppression capability and biosafety profile. GP262 can be used for leukemia and triple-negative breast cancer (TNBC) .
    GP262
  • HY-203618
    PI3K/mTOR ligand-1

    		Ligands for Target Protein for PROTAC mTOR PI3K Cancer
    PI3K/mTOR ligand-1 is a ligand for the target protein of PROTAC (PI3K/mTOR). PI3K/mTOR ligand-1 can be used to synthesize GP262 (HY-180261) .
    PI3K/mTOR ligand-1

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