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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
GPR75
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "GPR75" in MCE Product Catalog:
1
1 Cited Publications
Art. -Nr.: HY-160186
CAS. Nr.: 3084781-89-2
Target:
Forschungsgebiete:
20-SOLA is an orally active 20-HETE antagonist. 20-SOLA greatly ameliorates changes in blood pressure and renal injury associated with a Streptozotocin (STZ) (HY-13753)-diabetic mouse model. 20-SOLA facilitates the restoration of coronary collateral growth (CCG) after ischemic injury. 20-SOLA can be studied for research in cardiovascular diseases and diabetes .
Art. -Nr.: HY-RS05734
Target:
Forschungsgebiete:
GPR75 Human Pre-designed siRNA Set A contains three designed siRNAs for GPR75 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS17463
Target:
Forschungsgebiete:
Gpr75 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gpr75 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Target:
Forschungsgebiete:
20-HETE inhibitor-2 is an orally active 20-HETE inhibitor. 20-HETE inhibitor-2 can inhibit the activities of CYP4F2 and CYP4A11, thereby suppressing the production of 20-HETE. 20-HETE inhibitor-2 has the effect of improving blood glucose and can be used for the research of various diseases related to 20-HETE such as obesity .
Art. -Nr.: HY-160187A
CAS. Nr.: 3055022-23-3
(Rac)-AAA is a regulator and inhibitor targeting GPR75. By blocking the 20-HETE-induced downregulation of GPR75 expression, (Rac)-AAA effectively inhibits the activation of key downstream signaling pathways including EGFR, AKT, NF-κB and FAK. (Rac)-AAA reverses 20-HETE-mediated epithelial-mesenchymal transition, which is specifically characterized by downregulating vimentin (vimentin), upregulating E-Cadherin, as well as reducing MMP-2 activity and cancer cell migration ability. (Rac)-AAA also abolishes the 20-HETE-induced upregulation of HIC-5 expression and anchorage-independent growth, and modulates the subcellular localization of PKC-α and phosphorylated AKT. (Rac)-AAA is investigated in androgen-independent prostate cancer (castration-resistant prostate cancer) .
Art. -Nr.: HY-RS23921
Target:
Forschungsgebiete:
Gpr75 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gpr75 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-P703293
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Probable G-protein coupled receptor 75; GPR75; Homo sapiens; Human; G-protein coupled receptor; Receptor; Transducer
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
