1 Result for "

GSK 366

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "GSK 366" in MCE Product Catalog:

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Cat. No.: HY-119171
CAS No.: 1953157-39-5
Purity:  99.80%
Target:  

KMO

GSK 366 is a type II kynurenine-3-monooxygenase (KMO) inhibitor with IC50 values of 2.3 nM and 0.7 nM for human KMO and P. fluorescens-KMO (Pf-KMO). GSK 366 binds to KMO’s substrate site, prevents productive NADPH association, substrate binding, and FAD hydroperoxy species formation. GSK 366 does not stimulate hydrogen peroxide (H2O2) production and reduces H2O2 levels. GSK 366 can be used for the researches of inflammation and neurological disease, such as acute pancreatitis multiple organ dysfunction syndrome and Alzheimer’s disease .
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