2 Results for "

Glembatumumab

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Glembatumumab" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-141604
CAS No.: 1182215-65-1
Purity:  99.90%
Synonyms: CDX-011; CR011-vcMMAE
Glembatumumab vedotin (CDX-011) is an ADC comprising a fully human IgG2 monoclonal antibody (CR011) directed against glycoprotein NMB (GPNMB) and conjugated to the potent tubulinbinding cytotoxic agent MMAE via a protease-sensitive vc linker. Glembatumumab vedotin has potent anticancer effects .
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1
1 Cited Publications
Cat. No.: HY-P99205
CAS No.: 1020264-78-1

Target:  

ADC Antibodies

Research Areas:  

Cancer

Glembatumumab is a fully human IgG2 monoclonal antibody directed against the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma. Glembatumumab can be coupled to the microtubule inhibitor monomethyl auristatin E to form glembatumumab vedotin. Glembatumumab vedotin is an antibody-agent coupling (ADC) with antitumor activity .
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