136 Results for "

Glutor

" in MedChemExpress (MCE) Product Catalog:

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Glutor

Cat. No.: HY-158302

CAS No.: 2561471-22-3

Purity: ≥99.0%

Target:

GLUT Apoptosis

Research Areas:

Cancer

Glutor is a selective GLUT 1/2/3 inhibitor that can suppress glucose uptake. Glutor can inhibit glycolysis and has anti-tumor activity, inducing cell apoptosis .

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Streptozotocin

168 Publications Verification

Cat. No.: HY-13753

CAS No.: 18883-66-4

Purity: 99.20%

Synonyms: Streptozocin; NSC-85998; U 9889

Category:

Antibiotics Mammalian Cell Culture Microorganism Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer

Target:

DNA/RNA Synthesis DNA Alkylator/Crosslinker Autophagy Bacterial Antibiotic Apoptosis

Streptozotocin (Streptozocin; STZ) is an antibiotic widely used in experimental animal models of induced diabetes. Streptozotocin enters B cells via the glucose transporter (GLUT2) and causes the alkylation of DNA ( DNA-methylating ). Streptozotocin can induce the apoptosis of β cells .

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BAY-876

65 Cited Publications

Cat. No.: HY-100017

CAS No.: 1799753-84-6

Purity: 99.67%

Target:

GLUT Disulfidptosis

Research Areas:

Cancer

BAY-876, a chemical probe, is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC₅₀ of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. In addition, BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis .

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Phloretin

32 Cited Publications

Cat. No.: HY-N0142

CAS No.: 60-82-2

Synonyms: NSC 407292; RJC 02792

Category:

Rosaceae Extract Dihydrochalcones Endogenous metabolite Malus pumila Mill. Extract Human Gut Microbiota Metabolites Plant Flavonoids Phenols Polyphenols Disease Research Fields Cancer

Target:

SGLT Endogenous Metabolite GLUT

Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill.，has anti-inflammatory activities. Phloridzin is a specific，competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC₅₀values of 49 μM and 61 μM，respectively .Phloretin has the potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation .

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WZB117

27 Cited Publications

Cat. No.: HY-19331

CAS No.: 1223397-11-2

Target:

GLUT

Research Areas:

Cancer

WZB117 is a glucose transporter 1 (Glut1) inhibitor, which downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo.

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STF-31

19 Cited Publications

Cat. No.: HY-18728

CAS No.: 724741-75-7

Target:

GLUT Autophagy

Research Areas:

Cancer

STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC₅₀ of 1 μM. STF-31 is also a NAMPT inhibitor. STF-31 inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells .

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Phlorizin

18 Cited Publications

Cat. No.: HY-N0143

CAS No.: 60-81-1

Synonyms: Floridzin

Category:

Malus pumila Mill. Extract Plant Flavonoids Rosaceae Extract Metabolic Disease Phenols Polyphenols Dihydrochalcones Disease Research Fields

Target:

Caspase JAK GLUT STAT Apoptosis Bacterial SGLT mTOR Akt NF-κB PI3K DNA/RNA Synthesis

Phlorizin (Floridzin) is an orally active non-selective sodium-glucose cotransporter (SGLT) inhibitor, with an IC₅₀ of 0.04 μM and a K_i of 39 nM against hSGLT2, and an IC₅₀ of 0.17 μM and a K_i of 0.31 μM against hSGLT1. Phlorizin promotes GLUT4 translocation, inhibits gluconeogenesis and promotes glycogen synthesis by activating the PI3K/Akt/mTOR pathway. Phlorizin reduces DNA damage and apoptosis (apoptosis) by inhibiting the NF-κB inflammatory pathway. Phlorizin induces apoptosis via activating the Caspase pathway by antagonizing the JAK/STAT3 and PCK pathways. Phlorizin also exhibits antibacterial, anti-inflammatory and neuroprotective activities .

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Phlorizin dihydrate

18 Cited Publications

Cat. No.: HY-N0143A

CAS No.: 7061-54-3

Synonyms: Floridzin dihydrate

Phlorizin (Floridzin) dihydrate is an orally active non-selective sodium-glucose cotransporter (SGLT) inhibitor, with an IC₅₀ of 0.04 μM and a K_i of 39 nM against hSGLT2, and an IC₅₀ of 0.17 μM and a K_i of 0.31 μM against hSGLT1. Phlorizin dihydrate promotes GLUT4 translocation, inhibits gluconeogenesis and promotes glycogen synthesis by activating the PI3K/Akt/mTOR pathway. Phlorizin dihydrate reduces DNA damage and apoptosis (apoptosis) by inhibiting the NF-κB inflammatory pathway. Phlorizin dihydrate induces apoptosis via activating the Caspase pathway by antagonizing the JAK/STAT3 and PCK pathways. Phlorizin dihydrate also exhibits antibacterial, anti-inflammatory and neuroprotective activities .

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CTPI-2

17 Cited Publications

Cat. No.: HY-123986

CAS No.: 68003-38-3

Purity: 99.95%

Target:

Mitochondrial Metabolism

Research Areas:

Inflammation/Immunology Cancer

CTPI-2 is a third-generation mitochondrial citrate carrier SLC25A1 inhibitor with a K_D of 3.5 μM. CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 halts salient alterations of NASH reverting steatosis, preventing the evolution to steatohepatitis, reducing inflammatory macrophage infiltration in the liver and adipose tissue, and starkly mitigating obesity induced by a high-fat diet. Antitumor activity .

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(-)-Epicatechin gallate

9 Cited Publications

Cat. No.: HY-N0002

CAS No.: 1257-08-5

Synonyms: Epicatechin gallate; ECG; (-)-Epicatechin 3-O-gallate

Category:

Plant Flavonoids Flavanols Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Extract Disease Research Fields Cancer Theaceae Extract

Target:

COX Autophagy Virus Protease GLUT

(-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 7.5 μM . (-)-Epicatechin gallate is a GLUT1 and GLUT5 inhibitor. (-)-Epicatechin gallate decreases cell growth of GLUT5-expressing hxt ⁰ yeast cells .

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KL-11743

8 Cited Publications

Cat. No.: HY-145597

CAS No.: 1369452-53-8

Purity: 99.40%

Target:

GLUT Disulfidptosis

Research Areas:

Metabolic Disease Cancer

KL-11743 is a potent, orally active, and glucose-competitive inhibitor of the class I glucose transporters, with IC₅₀s of 115, 137, 90, and 68 nM for GLUT1, GLUT2, GLUT3, and GLUT4, respectively. KL-11743 specifically blocks glucose metabolism. KL-11743 can synergize with electron transport inhibitors to induce cell death. In addition, KL-11743 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis .

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Fenbendazole-d3

7 Cited Publications

Cat. No.: HY-B0413S

CAS No.: 1228182-47-5

Fenbendazole-d₃ is a deuterium labeled Fenbendazole. Fenbendazole-d₃ is a HIF-1α agonist and activates the HIF-1α-related GLUT1 pathway. Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53 .

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Gamma-glutamylcysteine

5 Cited Publications

Cat. No.: HY-113402

CAS No.: 636-58-8

Purity: 95.20%

Synonyms: γ-Glu-Cys

Category:

Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Microorganism Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite Interleukin Related TNF Receptor AMPK Sirtuin STAT PI3K NF-κB JAK p38 MAPK JNK Akt Apoptosis Ferroptosis

Gamma-glutamylcysteine (γ-Glu-Cys) is an orally active, blood-brain barrier permeable dipeptide . Gamma-glutamylcysteine activates AMPK, SIRT1, IL-4/STAT6, AC/cAMP/PI3K, IGF-1R/IRS1/PI3K, and Nrf2 signaling pathways; it inhibits NF-κB, JAK1/STAT1/3, MAPKs, cadmium-induced p38 MAPK, JNK, and PI3K/Akt signaling pathways. Gamma-glutamylcysteine regulates macrophage polarization, modulates the trafficking of CD36 and GLUT4, induces glutathione synthesis, improves metabolic dysfunction, reduces lipid deposition, ameliorates glucose homeostasis, inhibits apoptosis (Apoptosis), stabilizes mitochondria, suppresses lipid peroxidation, iron accumulation and ferroptosis (Ferroptosis), reduces ds-HMGB1 levels, reverses mechanical hyperalgesia, and alleviates hepatic lipid droplet formation. Gamma-glutamylcysteine is applicable to research related to inflammatory bowel disease, type 2 diabetes, cadmium-induced neurotoxicity, Alzheimer's disease, cerebral ischemia/reperfusion injury, neuropathy, and alcoholic liver disease .

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Gamma-glutamylcysteine TFA

5 Cited Publications

Cat. No.: HY-113402A

CAS No.: 283159-88-6

Purity: 95.20%

Synonyms: γ-Glu-Cys TFA

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Gamma-glutamylcysteine TFA (γ-Glu-Cys TFA) is an orally active, blood-brain barrier permeable dipeptide . Gamma-glutamylcysteine TFA activates AMPK, SIRT1, IL-4/STAT6, AC/cAMP/PI3K, IGF-1R/IRS1/PI3K, and Nrf2 signaling pathways; it inhibits NF-κB, JAK1/STAT1/3, MAPKs, cadmium-induced p38 MAPK, JNK, and PI3K/Akt signaling pathways. Gamma-glutamylcysteine TFA regulates macrophage polarization, modulates the trafficking of CD36 and GLUT4, induces glutathione synthesis, improves metabolic dysfunction, reduces lipid deposition, ameliorates glucose homeostasis, inhibits apoptosis (Apoptosis), stabilizes mitochondria, suppresses lipid peroxidation, iron accumulation and ferroptosis (Ferroptosis), reduces ds-HMGB1 levels, reverses mechanical hyperalgesia, and alleviates hepatic lipid droplet formation. Gamma-glutamylcysteine TFA is applicable to research related to inflammatory bowel disease, type 2 diabetes, cadmium-induced neurotoxicity, Alzheimer's disease, cerebral ischemia/reperfusion injury, neuropathy, and alcoholic liver disease .

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Fasentin

4 Cited Publications

Cat. No.: HY-101849

CAS No.: 392721-37-8

Purity: ≥98.0%

Target:

GLUT TNF Receptor Apoptosis

Research Areas:

Cardiovascular Disease Cancer

Fasentin, a potent glucose uptake inhibitor, inhibits GLUT-1/GLUT-4 transporters. Fasentin preferentially inhibits GLUT4 (IC₅₀=68 μM) over GLUT1. Fasentin is a death receptor stimuli (FAS) sensitizer and sensitizes cells to FAS-induced cell death. Fasentin is also a tumor necrosis factor (TNF) apoptosis-inducing ligand sensitizer. Fasentin blocks glucose uptake in cancer cell lines and has anti-angiogenic activity .

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Flavokawain C

4 Cited Publications

Cat. No.: HY-N2445

CAS No.: 37308-75-1

Category:

Piperaceae Extract Other Families Extract Piper methysticum G.Forst. Extract Plant Flavonoids Chalcones Phenols Polyphenols Disease Research Fields Cancer

Target:

Apoptosis Akt JNK PERK Caspase PARP MDM-2/p53 IAP Reactive Oxygen Species (ROS) SOD FABP Autophagy AMPK mTOR GLUT EGFR PI3K HSP VEGFR FAK

Flavokawain C is an orally active natural chalcone. Flavokawain C inhibits the proliferation of various cancer cells. Flavokawain C upregulates GADD153 in cancer cells, inhibits the phosphorylation of Akt and JNK, suppresses early ERK phosphorylation, activates late ERK phosphorylation, activates caspase related subtypes, induces PARP-1 cleavage, causes upregulation of p21 and p27, downregulation of mutant p53 and anti-apoptotic IAP proteins, elevates intracellular ROS levels, reduces SOD activity, and induces apoptosis. Flavokawain C downregulates FABP4, induces autophagy in cancer cells, and activates the AMPK/mTOR pathway . Flavokawain C decreases the expression of glycolysis-related proteins GLUT1 and HK2, and inhibits glycolysis in nasopharyngeal carcinoma cells. Flavokawain C inhibits the activation of the EGFR/PI3K/Akt/mTOR signaling pathway and reduces the expression of HSP90B1. Flavokawain C inhibits angiogenesis by decreasing the expression of angiogenic proteins Ang-1 and VEGF in human umbilical vein endothelial cells. Flavokawain C increases γ-H2AX levels in cells, inhibits the phosphorylation of FAK, PI3K and AKT in cells, and induces DNA damage in cells. Flavokawain C exerts anti-tumor activity in multiple tumor xenograft mouse models. Flavokawain C is applicable to research related to colorectal cancer, colon adenocarcinoma, nephroblastoma, nasopharyngeal carcinoma and liver cancer .

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Marein

3 Cited Publications

Cat. No.: HY-N7676

CAS No.: 535-96-6

Category:

Cardiovascular Disease Plant Flavonoids Chalcones Neurological Disease Phenols Polyphenols Other Families Extract Disease Research Fields

Target:

AMPK HDAC

Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC₅₀ of 100 μM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects .

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p-Synephrine

3 Cited Publications

Cat. No.: HY-113236

CAS No.: 614-35-7

Purity: 98.04%

Category:

Rutaceae Extract Citrus × aurantium Linnaeus Extract Endogenous metabolite Alkaloids Plant Monophenols Other Alkaloids Other Diseases Phenols Disease Research Fields

Target:

Adrenergic Receptor AMPK GLUT p38 MAPK NF-κB

p-Synephrine is an orally active alkaloid dietary supplement without indirect sympathomimetic activity or cardiovascular stimulatory activity. p-Synephrine stimulates AMPK phosphorylation and mediates Glut4 translocation to increase glucose consumption and lactate production in skeletal muscle cells. p-Synephrine also downregulates the p38 MAPK and NF-κB signaling pathways to inhibit pro-inflammatory cytokine production and alter oxidative metabolism. p-Synephrine exhibits low subchronic toxicity in mice. p-Synephrine can be applied to research related to systemic inflammatory response syndrome, obesity, and type 2 diabetes .

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Licoflavone A

3 Cited Publications

Cat. No.: HY-N4185

CAS No.: 61153-77-3

Category:

Leguminosae/Fabaceae Extract Plant Flavonoids Neurological Disease Flavones Glycyrrhiza uralensis Fisch. Extract Phenols Polyphenols Disease Research Fields

Target:

Phosphatase VEGFR PI3K Akt MEK ERK Apoptosis HIF/HIF Prolyl-Hydroxylase GLUT Lactate Dehydrogenase Pyruvate Kinase Hexokinase c-Myc Bcl-2 Family

Licoflavone A is an orally active PTP1B/VEGFR-2 inhibitor, with an IC₅₀ of 54.5 μM against PTP1B, an IC₅₀ of 14.36 μM and a K_d of 142.38 nM against human VEGFR-2. Licoflavone A blocks the PI3K/AKT and MEK/ERK signaling pathways. Licoflavone A induces G1 phase cell cycle arrest, apoptosis via the intrinsic mitochondrial pathway (apoptosis), and inhibits migration, invasion and epithelial-mesenchymal transition (EMT) of gastric cancer cells. Licoflavone A inhibits the proliferation of gastric cancer cells in vitro and in xenograft models. Licoflavone A reduces the expression levels of HIF-1α, GLUT1, LDHA, PKM2 and HK2 in hypoxic gastric cancer cells, decreases glucose uptake and suppresses glycolysis. Licoflavone A can be used in research related to gastric cancer, type 2 diabetes and obesity .

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Rubusoside

2 Cited Publications

Cat. No.: HY-N0668

CAS No.: 64849-39-4

Category:

Plant Terpenoids Other Diseases Diterpenoids Other Families Extract Disease Research Fields Sweeteners Food Research

Target:

GLUT Amylases NF-κB

Rubusoside is a diterpene glycoside that is also a sweetener and solubilizer with anti-angiogenic, anti-cancer, anti-obesity, anti-allergic and anti-asthmatic effects. Rubusoside attenuates airway hyperresponsiveness and reduces inflammatory cells in bronchoalveolar lavage fluid (BALF), reducing OVA (HY-W250978)-induced airway inflammation. Rubusoside also prevents palmitic acid-induced lipotoxicity in pancreatic INS-1 cells, reduces the transport of human glucose transporters GLUT-1 and fructose GLUT-5, and inhibits NF-κB and α-amylase (α-amylase) .

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