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Results for "

HBG

" in MedChemExpress (MCE) Product Catalog:

4

Inhibitors & Agonists

1

Recombinant Proteins

1

Antibodies

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-167874
    ASP-8731

    		Heme Oxygenase (HO) NF-κB Transmembrane Glycoprotein Cardiovascular Disease
    ASP-8731 is an orally active BACH1 inhibitor. ASP-8731 activates antioxidant, anti-inflammatory and globin gene pathways by relieving the inhibitory effect of BACH1 on NRF2-mediated gene transcription. ASP-8731 significantly upregulates the expression of HMOX1, FTH1 and various globins (such as HGB, HBG, HBA), increases fetal hemoglobin (HbF) levels, and effectively induces F-cell production in hydroxyurea-unresponsive cells. Meanwhile, ASP-8731 reduces inflammatory responses and white blood cell counts by downregulating VCAM1, ICAM-1 and the phosphorylation level of NF-κB(p65), and blocks heme-induced glutathione depletion and microcirculatory stasis. ASP-8731 holds potential for inhibiting sickle cell disease and related hematological disorders .
    ASP-8731
  • HY-159099
    WIZ degrader 9

    		Molecular Glues Histone Acetyltransferase Cardiovascular Disease
    WIZ degrader 9 is an orally active molecular glue degrader of the WIZ transcription factor. As a molecular glue, WIZ degrader 9 recruits WIZ to the cereblon E3 ubiquitin ligase complex via its ZF7 domain, driving proteasome-dependent degradation of WIZ. WIZ degrader 9 induces hemoglobin production, reduces the level of H3K9 dimethylation across the whole genome and at the β-globin locus, upregulates the transcription of γ-globin and BGLT3, and increases the level of histone H3K9 acetylation in the promoter region of HBG1/2. WIZ degrader 9 effectively induces fetal hemoglobin production in both mice and cynomolgus monkeys. WIZ degrader 9 can be used for research on sickle cell disease .
    WIZ degrader 9
  • HY-RS06030
    HBG1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    HBG1 Human Pre-designed siRNA Set A contains three designed siRNAs for HBG1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    HBG1 Human Pre-designed siRNA Set A
    HBG1 Human Pre-designed siRNA Set A
  • HY-RS06031
    HBG2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    HBG2 Human Pre-designed siRNA Set A contains three designed siRNAs for HBG2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    HBG2 Human Pre-designed siRNA Set A
    HBG2 Human Pre-designed siRNA Set A

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