3 Results for "

HBMEC

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "HBMEC" in MCE Product Catalog:

1
HSP90B1 Protein, Human (His, Strep)
HSP90B1 Protein, Human (His, Strep)
0 Images
1 Cited Publications
Cat. No.: HY-P703226
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HSP90B1; HEL35; Prev. TRA1; Heat Shock Protein 90kDa Beta Family Member 1; Endoplasmin; Stress-Inducible Tumor Rejection Antigen Gp96; GRP94; Endothelial Cell (HBMEC) Glycoprotein; Heat Shock Protein 90 KDa Beta Member 1; Epididymis Luminal Protein 35; GP
Species:  
Human
Source:  
E. coli
loading...
    loading...
View All Sizes
AM9928
AM9928
0 Images
Cat. No.: HY-182639
CAS No.: 1869033-49-7
Target:  

Exosomes MAGL Interleukin Related VEGFR

Research Areas:  

Cancer

AM9928 is a monoacylglycerol lipase (MAGL) inhibitor with IC50 and Ki values of 8.9 nM and 7.3 nM, respectively. AM9928 blocks the adhesion and migration of triple-negative breast cancer (TNBC) cells, and inhibits the secretion of IL-6, IL-8 and VEGF-A by TNBC cells. AM9928 suppresses the activation of human brain microvascular endothelial cells (HBMECs) induced by TNBC-derived exosomes, and reduces the secretion of IL-8 and VEGF-A by HBMECs. AM9928 attenuates changes in blood-brain barrier permeability, inhibits tumor growth in the mammary fat pad, and reduces brain colonization of TNBC. AM9928 can be used in studies related to triple-negative breast cancer .
loading...
    loading...
View All Sizes
11β,13-Dihydrolactucopicrin
11β,13-Dihydrolactucopicrin
0 Images
Cat. No.: HY-N9932
CAS No.: 125519-47-3
Category:  

Terpenoids Sesquiterpenes Plants Compositae Extract Sophora tomentosa L.

Target:  

Glycosidase Interleukin Related TNF Receptor BCRP

11β,13-Dihydrolactucopicrin is a sesquiterpene lactone and the main bitter component of chicory root. 11β,13-Dihydrolactucopicrin inhibits yeast α-glucosidase activity (IC50 = 27.49 μM) and inhibits Crz1 activation and nuclear accumulation. 1β,13-Dihydrolactucopicrin possesses blood-brain barrier penetration capacity in an in vitro HBMEC blood-brain barrier model and can generate cysteine-conjugated metabolites within brain microvascular endothelial cells. 11β,13-Dihydrolactucopicrin can regulate the lncRNA H19/miR-21-3p signaling axis; it upregulates the expression of ABCG2 and lncRNA H19, downregulates miR-21-3p, inhibits the release of IL-6, TNF-α, and hs-CRP pro-inflammatory mediators, and alleviates urate-induced inflammatory injury in renal epithelial cells. 11β,13-Dihydrolactucopicrin can be used in research on diabetes and renal urate deposition .
loading...
    loading...
View All Sizes
Assay Types