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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
43 Results for "
Histone-lysine methyltransferase
" in MedChemExpress (MCE) Product Catalog:
Products (43)
43 Results for "Histone-lysine methyltransferase" in MCE Product Catalog:
Target:
Research Areas:
BIX-01338 hydrate is a histone lysine methyltransferase inhibitor.
Target:
Research Areas:
LEM-14 is a potent and selective NSD2 inhibitor with an IC50 of 132 µM. LEM-14 has very weak activitv
against NSD1 and has no activity against NSD3. LEM-14 inhibits fibrotic gene expression in ND but not DIO BMDMs. LEM-14 combined with ionizing radiation (IR) enhances the apoptosis rate and reduces the colony-formation ability of CRC cells. LEM-14 exhibits enhanced anti-tumor efficacy in Balb/c nude mice bearing LoVo cell xenografts when combined with ionizing radiation. LEM-14 has the potential for the research of multiple myeloma and colorectal cancer .
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ZZM-1220 is a histone lysine methyltransferase G9a/GLP covalent inhibitor with IC50s of of 458 nM and 924 nM, respectively. ZZM-1220 inhibits H3K9me2 in cells and significantly induces apoptosis of triple-negative breast cancer (TNBC) cells and blocks the cell cycle in the G2/M phase .
Cat. No.: HY-44062
CAS No.: 1350752-07-6
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G9a-IN-1 (Compound 113) is a G9a protein inhibitor. G9A/EHMT2 is a nuclear histone lysine methyltransferase that catalyzes histone H3 lysine 9 dimethylation (H3K9me2), which is a reversible modification generally associated with transcriptional gene silencing. G9a-IN-1 can be used for the research of autoimmune disorders or cancer .
Cat. No.: HY-W516880
CAS No.: 73736-50-2
Synonyms: O-Demethylastemizole
Research Areas:
Desmethylastemizole (O-Demethylastemizole) , a metabolite of Astemizole (HY-12532), is a β-hematin (βH) inhibitor. Desmethylastemizole has an antiplasmodium activity against P. falciparum with IC50 of 0.12, 0.11 and 0.06 μM for Pf3D7, PfDd2, and PfItG strains, respectively. Desmethylastemizole is also a Histamine H1 receptor antagonist. Desmethylastemizole significantly blocks hERG K + channels and also inhibits histone-lysine N-methyltransferase EZH2 activity. Desmethylastemizole can be used for long QT syndrome and malaria research .
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LEM-14-1189, a LEM-14 (HY-114340) derivative, is a NSDs inhibitor with IC50s of 418 μM (NSD1), 111 μM (NSD2), and 60 μM (NSD3), respectively. The NSDs, histone lysine methyltransferases (HMTases), are oncoproteins, drivers of a number of tumors. LEM-14-1189 can be used for multiple myeloma (MM) research .
Cat. No.: HY-111544
CAS No.: 2328074-38-8
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EML741 is a histone lysine methyltransferase G9a/GLP inhibitor, with an IC50 of 23 nM, Kd of 1.13 μM for G9a. EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barrier penetrated .
Cat. No.: HY-10587A
CAS No.: 1808255-64-2
Research Areas:
BIX-01294 hydrochloride hydrate is a histone-lysine methyltransferase (HMTase) inhibitor, which selective inhibits the G9aHMTase with IC50 of 1.7 μM, reduces histone-3 lysine (9) methylation (H3K9me), induces autophagy and apoptosis in human glioma cells .
Cat. No.: HY-P701589
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KMT2D; Trinucleotide Repeat Containing 21; Prev. MLL2; [Histone H3]-lysine(4) N-methyltransferase; Prev. TNRC21; Histone-lysine N-methyltransferase MLL2; Histone-lysine N-methyltransferase 2D; Histone-lysine N-methyltransferase 2C; MLL4; Truncated lysine
Species:
Human
Source:
E. coli
Cat. No.: HY-P701590
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KMT2D; Trinucleotide Repeat Containing 21; Prev. MLL2; [Histone H3]-lysine(4) N-methyltransferase; Prev. TNRC21; Histone-lysine N-methyltransferase MLL2; Histone-lysine N-methyltransferase 2D; Histone-lysine N-methyltransferase 2C; MLL4; Truncated lysine
Species:
Human
Source:
E. coli
Cat. No.: HY-113786
CAS No.: 923894-97-7
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Research Areas:
EZH2-IN-21 is a potent inhibitor of the histone lysine methyltransferase enhancer of zeste homologue 2 (EZH2) with anticancer activity. EZH2-IN-21 is competitive with the cofactor SAM and noncompetitive with peptide or nucleosome substrates .
Cat. No.: HY-116605
CAS No.: 1346704-13-9
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Research Areas:
GSK926 (compound 3) is a selective histone lysine methyltransferase EZH2 inhibitor (IC50=0.02 μM; Ki=7.9 nM), with SAM-competitive and cell-active properties. GSK926 can be used in cancer research .
Cat. No.: HY-156455
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SETD7-IN-1 (compound 7) is a PFI-2 (HY-18627) analogue. SETD7-IN-1 is a substrate and inhibitor of histone lysine methyltransferase SETD7, with an IC50 of 0.96 ± 0.10 µM .
Cat. No.: HY-150680
CAS No.: 2816165-02-1
Research Areas:
SARS-CoV-2 nsp14-IN-1 (Compound 3) is a prototypic bisubstrate inhibitor of SARS-CoV-2 Nsp14 MTase with an IC50 value of 0.061 μM. SARS-CoV-2 nsp14-IN-1 (Compound 3) has an excellent selectivity profile over a panel of human methyltransferases, can against apanel of 10 human MTases including histone lysine, proteinarginine, and DNA and RNA MTases .
Cat. No.: HY-P703634
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KMT2C; Homologous To ALR Protein; Prev. MLL3; Myeloid/Lymphoid Or Mixed-Lineage Leukemia 3; Histone-lysine N-methyltransferase 2C; [Histone H3]-lysine(4) N-methyltransferase; HALR; Histone-lysine N-methyltransferase MLL3; KIAA1506; lysine N-Methyltransfer
Species:
Human
Source:
E. coli
Cat. No.: HY-P702887
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: KMT2C; Homologous To ALR Protein; Prev. MLL3; Myeloid/Lymphoid Or Mixed-Lineage Leukemia 3; Histone-lysine N-methyltransferase 2C; [Histone H3]-lysine(4) N-methyltransferase; HALR; Histone-lysine N-methyltransferase MLL3; KIAA1506; lysine N-Methyltransfer
Species:
Human
Source:
E. coli
Cat. No.: HY-P85132
Synonyms: EHMT1; EUHMTASE1; GLP; KIAA1876; KMT1D; Histone-lysine N-methyltransferase EHMT1; Euchromatic Histone-lysine N-methyltransferase 1; Eu-HMTase1; G9a-like protein 1; GLP; GLP1; Histone H3-K9 methyltransferase 5; H3-K9-HMTase 5; lysine N-methy
Cat. No.: HY-P76062
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: SETD7; KIAA1717; SET Domain Containing 7, Histone lysine methyltransferase; Set9; SET7/9; SET Domain Containing lysine methyltransferase 7; SET7; lysine N-methyltransferase 7; KMT7; H3-K4-HMTase SETD7; Histone-lysine N-methyltransferase SETD7; SET Domain
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
