607 Results for "

Hydrogen

" in MedChemExpress (MCE) Product Catalog:
Products (607)

607 Results for "Hydrogen" in MCE Product Catalog:

49
GLX351322
GLX351322
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49 Publications Verification
Cat. No.: HY-100111
CAS No.: 835598-94-2
Pureté:  99.48%
Target:  

NADPH Oxidase

Domaines de recherche:  

Metabolic Disease

GLX351322 is an inhibitor of NADPH oxidase 4 (Nox4), and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μM.
46
DPPH
DPPH
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46 Cited Publications
Cat. No.: HY-112053
CAS No.: 1898-66-4
Pureté:  98.77%
Synonyms: 2,2-Diphenyl-1-picrylhydrazyl
Target:  

Reactive Oxygen Species (ROS)

Domaines de recherche:  

Metabolic Disease

DPPH (2,2-Diphenyl-1-picrylhydrazyl) is a stable free radical that can be used to measure the radical scavenging activity of antioxidants. The odd electron of nitrogen atom in DPPH is reduced by receiving a hydrogen atom from antioxidants to the corresponding hydrazine. DPPH method may be utilized in aqueous and nonpolar organic solvents and can be used to examine both hydrophilic and lipophilic antioxidants .
31
Clopidogrel hydrogen sulfate
Clopidogrel hydrogen sulfate
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31 Cited Publications
Cat. No.: HY-17459
CAS No.: 120202-66-6
Synonyms: (S)-(+)-Clopidogrel bisulfate; (S)-(+)-Clopidogrel Hydrogen sulfate
Target:  

Cytochrome P450 P2Y Receptor

Domaines de recherche:  

Cardiovascular Disease Cancer

Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively . Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation ．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor .
28
1,3-Diphenylisobenzofuran
1,3-Diphenylisobenzofuran
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28 Cited Publications
Cat. No.: HY-W011664
CAS No.: 5471-63-6
Synonyms: DPBF
1,3-Diphenylisobenzofuran (DPBF) has been developed as a selective probe for the detection and quantitative determination of hydrogen peroxide in samples containing different reactive nitrogen and oxygen species (RNOS). DPBF is a fluorescent probe which, for almost 20 years, was believed to react in a highly specific manner toward some reactive oxygen species such as singlet oxygen and hydroxy, alkyloxy or alkylperoxy radicals .
18
NADPH
NADPH
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18 Cited Publications
Cat. No.: HY-113324
CAS No.: 53-57-6
Pureté:  99.49%
Category:  

Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite

Target:  

Endogenous Metabolite

NADPH is a coenzyme of glutathione reductase (GR), thioredoxin reductase (TrxR) and NADPH oxidase (NOX), and participates in redox reactions as a hydrogen donor. NADPH has the characteristic of selectively participating in the regulation of cellular redox homeostasis. NADPH exerts antioxidant activity and resists reactive oxygen species (ROS) damage by providing reducing equivalents for the regeneration of glutathione (GSH) and thioredoxin (Trx); at the same time, it acts as a substrate of NOX to generate superoxide anions, mediating oxidative stress and immune response. NADPH participates in maintaining the intracellular reducing environment, biosynthesis and regulating gene expression (such as the Nrf2 pathway), and is mainly used in the study of oxidative stress-related diseases (such as cardiovascular diseases, neurodegenerative diseases, cancer) and immune regulation mechanisms .
15
Papain
Papain
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15 Cited Publications
Cat. No.: HY-P1645
CAS No.: 9001-73-4
Category:  

Carica papaya L. Natural Products Caricaceae Plants Disease Research Fields Inflammation/Immunology

Target:  

Cathepsin

Papain is a cysteine protease of the peptidase C1 family. Papain enhances red cell agglutination by anti-D and anti-A, and increases red cell sensitivity to K cell-mediated lysis in ADCC assays. Papain can induce pulmonary emphysema. Papain can be used for the researches of Rh haemolytic disease of the newborn and pulmonary emphysema .
12
L-Cysteine
L-Cysteine
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12 Cited Publications
Cat. No.: HY-Y0337
CAS No.: 52-90-4
Synonyms: Cysteine
Category:  

Human Gut Microbiota Metabolites Microorganisms Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields

Target:  

Environmental Pollutants Endogenous Metabolite

L-Cysteine (Cysteine) is an orally active conditionally essential amino acid with hypoglycemic effects, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/H2S pathway. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans. L-Cysteine can be used as an anorectic agent .
12
L-Cysteine hydrochloride
L-Cysteine hydrochloride
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12 Cited Publications
Cat. No.: HY-Y0337A
CAS No.: 52-89-1
Category:  

Anti-aging Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

L-Cysteine hydrochloride is an orally active conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB synthesis by disrupting cell structure and antioxidant system balance. L-Cysteine hydrochloride enhances relaxant responses of rat aortic rings to NO and reduces responses to endothelium-derived relaxing factor (EDRF) .
12
L-Cysteine hydrochloride hydrate
L-Cysteine hydrochloride hydrate
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12 Cited Publications
Cat. No.: HY-W016715
CAS No.: 7048-04-6
Category:  

Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite NF-κB Insulin Receptor

L-Cysteine hydrochloride hydrate is an orally active and essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride hydrate regulates CBS/H2S pathway, inhibits NF-κB activation and insulin and ghrelin secretion. L-Cysteine hydrochloride hydrate reduces blood sugar, vascular inflammation markers and appetite. L-Cysteine hydrochloride hydrate induces kidney damage. L-Cysteine hydrochloride hydrate can be used in the study of neurological diseases and diabetes .
11
N-Acetyl-L-cysteine ethyl ester
N-Acetyl-L-cysteine ethyl ester
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11 Cited Publications
Cat. No.: HY-134495
CAS No.: 59587-09-6
Pureté:  98.26%
Synonyms: N-Acetylcysteine ethyl ester; NACET
Target:  

Reactive Oxygen Species (ROS)

Domaines de recherche:  

Metabolic Disease

N-Acetyl-L-cysteine ethyl ester is an esterified form of N-acetyl-L-cysteine (NAC). N-Acetyl-L-cysteine ethyl ester exhibits enhanced cell permeability, and produce NAC and cysteine. N-Acetyl-L-cysteine ethyl ester increases circulating hydrogen sulfide (H2S) and can be used as an H2S producer. N-Acetyl-L-cysteine ethyl ester has the potential to substitute NAC as a mucolytic agent, and as a GSH-related antioxidant .
10
Pterostilbene
Pterostilbene
0 Images
10 Cited Publications
Cat. No.: HY-N0828
CAS No.: 537-42-8
Category:  

other families Monophenols Stilbenes Phenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Autophagy

Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium . Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties . Pterostilbene blocks ROS production , also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide .
9
Lipoamide
Lipoamide
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9 Cited Publications
Cat. No.: HY-B1142
CAS No.: 940-69-2
Synonyms: (±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide
Category:  

Human Gut Microbiota Metabolites Natural Products Microorganisms Other Diseases Endogenous metabolite Disease Research Fields

Target:  

NO Synthase

Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway .
9
Tetrazolium Red
Tetrazolium Red
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9 Cited Publications
Cat. No.: HY-D0714
CAS No.: 298-96-4
Synonyms: 2,3,5-Triphenyltetrazolium chloride; TPTZ; TTC
Tetrazolium Red (2,3,5-Triphenyltetrazolium chloride; TTC) is a not brain-penetrant, colorless, water-soluble dye that is reduced by mitochondrial enzymes to a deep red, water-insoluble compound (formazan) mainly in the mitochondria of living cells. Tetrazolium Red is used to observe the activity of dehydrogenase, and it turns colorless to red when exposed to hydrogen. Tetrazolium Red distinguishes between surviving and infarcted brain tissue after stroke. Tetrazolium Red has been used to stain heart tissue to measure the extent of acute lesions and also used to stain brain tissue to detect the size of the infarcted area. The absorption wavelength of Tetrazolium Red is 570 nm .
8
Ammonium citrate dibasic, 99%
Ammonium citrate dibasic, 99%
0 Images
8 Cited Publications
Cat. No.: HY-B1529
CAS No.: 3012-65-5
Synonyms: Ammonium Hydrogencitrate, 99%; Diammonium Hydrogen citrate, 99%
Ammonium citrate dibasic, 99% (Ammonium hydrogencitrate, 99%) can be used as the carbon source to prepare carbon quantum dots (CDs). Ammonium citrate dibasic, 99% is a buffering agent .
8
DMNQ
DMNQ
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8 Cited Publications
Cat. No.: HY-121026
CAS No.: 6956-96-3
Pureté:  98.69%
Target:  

Reactive Oxygen Species (ROS) ROS Kinase

Domaines de recherche:  

Cardiovascular Disease

DMNQ is a redox cycling agent. DMNQ produces hydrogen peroxide in cells in a concentration-dependent manner. DMNQ can induce the increase of ROS production .
8
Inclisiran
Inclisiran
0 Images
8 Cited Publications
Cat. No.: HY-132591
CAS No.: 1639324-58-5
Pureté:  99.80%
Synonyms: ALN-PCSsc
Target:  

PCSK9 Small Interfering RNA (siRNA) Pyroptosis PPAR NOD-like Receptor (NLR) Caspase Interleukin Related

Domaines de recherche:  

Cardiovascular Disease Metabolic Disease

Inclisiran is a double-stranded small interfering RNA (siRNA) molecule. Inclisiran inhibits the transcription of PCSK9. Inclisiran inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, IL-1β, and IL-18. Inclisiran has anti-inflammatory, lipid-regulating and anti-atherosclerotic activities. Inclisiran can be used in researches of hyperlipidemia and cardiovascular disease (CVD) .
8
Tenapanor
Tenapanor
0 Images
8 Cited Publications
Cat. No.: HY-15991
CAS No.: 1234423-95-0
Synonyms: AZD1722; RDX5791
Target:  

Na+/H+ Exchanger (NHE)

Domaines de recherche:  

Metabolic Disease

Tenapanor (AZD1722) is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor has the potential for the research of hyperphosphatemia .
8
Tenapanor hydrochloride
Tenapanor hydrochloride
0 Images
8 Cited Publications
Cat. No.: HY-15991A
CAS No.: 1234365-97-9
Synonyms: AZD1722 hydrochloride; RDX5791 hydrochloride
Target:  

Na+/H+ Exchanger (NHE)

Domaines de recherche:  

Metabolic Disease

Tenapanor (AZD1722) hydrochloride is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor hydrochloride reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor hydrochloride has the potential for the research of hyperphosphatemia .
7
Glucose oxidase
Glucose oxidase
0 Images
7 Cited Publications
Cat. No.: HY-P2902
CAS No.: 9001-37-0
Target:  

Endogenous Metabolite

Domaines de recherche:  

Cancer

Glucose oxidase is used in the food and beverage industry as a preservative and stabilizer and is commonly derived from the fungus Aspergillus niger. Glucose oxidase can react with intracellular glucose and oxygen (O2) to produce hydrogen peroxide (H2O2) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit their proliferation .
6
AP39
AP39
0 Images
6 Cited Publications
Cat. No.: HY-126124
CAS No.: 1429061-80-2
Pureté:  96.35%
Target:  

Reactive Oxygen Species (ROS)

Domaines de recherche:  

Cardiovascular Disease Neurological Disease

AP39 is a triphenylphosphonium derivatised anethole dithiolethione and mitochondria-targeting hydrogen sulfide (H2S) donor. AP39 increases intracellular H2S levels. AP39 exerts cytoprotective effects and maintains mitochondrial DNA integrity under oxidative stress conditions. AP39 protects against myocardial reperfusion injury in mice model and has the potential for Alzheimer's disease research .
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