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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
IL-13 signaling
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "IL-13 signaling" in MCE Product Catalog:
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1 Cited Publications
Cat. No.: HY-P990121
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Atinvicitinib is an orally active and selective JAK1 inhibitor. Atinvicitinib blocks signaling of JAK1-dependent pruritogenic and pro-inflammatory cytokines, including those in the IL-31, IL-4, and IL-13 pathways. Atinvicitinib can be used for the researches of pruritus associated with allergic dermatitis and canine atopic dermatitis .
Cat. No.: HY-P990748
CAS No.: 2770858-49-4
Synonyms: SAR443765
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Cat. No.: HY-P990735
CAS No.: 2765066-99-5
Synonyms: UCB-1381
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Cat. No.: HY-P990090
CAS No.: 2648260-80-2
Synonyms: CBP-201
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iJak-381 is a JAK1/2 inhibitor with anti-inflammatory activity. iJak-381 blocks IL-13 signaling and also inhibits IL-4 and IL-6 signaling pathways. iJak-381 also reduced p-STAT6 levels and inhibited the influx of inflammatory cells into the lungs of mice. iJak-381 inhibits airway hyperresponsiveness (AHR) .
Cat. No.: HY-P991633
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Cat. No.: HY-P11147
CAS No.: 2319573-67-4
Cat. No.: HY-174637
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Human IL13RA2 mRNA encodes the human interleukin 13 receptor subunit alpha 2 (IL13RA2) protein, a subuint of the interleukin 13 receptor complex. IL13RA2 binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13.
Cat. No.: HY-174638
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Human IL13RA1 mRNA encodes the human interleukin 13 receptor subunit alpha 1 (IL13RA1) protein, a subunit of the interleukin 13 receptor. IL13RA1 serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. It has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.
Cat. No.: HY-P992034
Synonyms: PR001
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APG808 (PR001) is an anti-human IL-4Rα monoclonal antibody. APG808 binds to IL-4Rα, prevents IL-13Rα1/IL-4Rα heterodimer formation, and disrupts IL-13 and IL-4 mediated signaling. APG808 ablates Fc and complement effector functions. APG808 can be used for the research of chronic obstructive pulmonary disease, asthma, atopic dermatitis .
Cat. No.: HY-181006
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TSLP modulator-1 (Compound 14O) is a potent TSLP signaling modulator. TSLP modulator-1 exhibits potent inhibition of CCL17 and IL-1β mRNA expression. TSLP modulator-1 attenuates the protein levels of IL-6, IL-4 and IL-13. TSLP modulator-1 significantly attenuates calcium influx. TSLP modulator-1 exerts anti-inflammatory effects. TSLP modulator-1 effectively alleviates pruritus and atopic dermatitis-like symptoms .
Cat. No.: HY-187160
CAS No.: 3104023-24-4
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IL-4-IN-2 (Compound 14/analog 14) is a selective IL-4 inhibitor. IL-4-IN-2 binds to soluble IL-4 and inhibits IL-4-mediated signal transduction. IL-4-IN-2 suppresses STAT-6 phosphorylation induced by IL-13 and IL-4 in monocytes and B lymphocytes. IL-4-IN-2 is applicable to the research of allergic inflammation, cancer, autoimmune diseases, asthma and arthritis .
Cat. No.: HY-P992132
CAS No.: 3057433-10-7
Synonyms: STAR-0310
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Cat. No.: HY-187103
CAS No.: 2241039-80-3
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JAK1-IN-22 is a JAK1-selective inhibitor with an IC50 of 1.84 μM. JAK1-IN-22 exerts no significant inhibitory effect on JAK2 and JAK3. JAK1-IN-22 can be used in the research of JAK1-related diseases such as asthma, alopecia areata, and type 1 diabetes .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
