2 Results for "

IL6/JAK1/STAT3 signal pathway

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "IL6/JAK1/STAT3 signal pathway" in MCE Product Catalog:

Azaleatin
Azaleatin
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Cat. No.: HY-N7653
CAS No.: 529-51-1
Category:  

Flavonols Flavonoids Carthamus tinctorius L. Metabolic Disease Phenols Polyphenols Plants Compositae Extract Disease Research Fields

Target:  

Dipeptidyl Peptidase NF-κB MyD88 JAK Toll-like Receptor (TLR) STAT Interleukin Related COX Reactive Oxygen Species (ROS) Glutathione S-transferase SOD Bcl-2 Family Caspase Apoptosis Dengue Virus

Azaleatin is an orally active inhibitor of hQC, NS2B-NS3 protease and E. coli β-glucuronidase, with IC50 values of 1.1 μM, 38.00 μg/mL and 0.57 μM, respectively. Azaleatin inhibits the activities of NF-κB, MyD88, JAK1, TLR4, STAT3, IL-1β, IL-6, COX-2, TNF-α and β-glucuronidase, blocks pro-inflammatory signaling pathways, reduces the levels of ROS, MDA and uric acid, elevates the levels of GPx, GSR, GST, SOD, CAT, HO-1 and GSH, scavenges free radicals and exerts reducing capacity. Azaleatin inhibits the expression of pro-apoptotic proteins Bax, Caspase-9 and Caspase-3, and upregulates the expression of anti-apoptotic protein Bcl-2. Azaleatin reduces the levels of cardiac injury markers, restores cardiac histological structure, inhibits Aβ aggregation, dengue protease activity, hepatic stellate cell proliferation and cancer cell growth, and also exhibits antibacterial activity. Azaleatin can be used in studies related to subchronic cardiotoxicity, Alzheimer's disease, dengue fever, hyperuricemia, liver fibrosis, gastric cancer and bacterial infections .
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PROTAC JAK1/2 degrader-1
PROTAC JAK1/2 degrader-1
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Cat. No.: HY-179715
Target:  

PROTACs JAK TNF Receptor Interleukin Related STAT

Research Areas:  

Inflammation/Immunology

PROTAC JAK1/2 degrader-1 is an orally active JAK1/JAK2 PROTAC degrader, with DC50 values of 1.4 μM and 0.92 μM against JAK1 and JAK2, respectively. PROTAC JAK1/2 degrader-1 triggers degradation via a CRBN- and proteasome-dependent pathway. PROTAC JAK1/2 degrader-1 inhibits the secretion of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). PROTAC JAK1/2 degrader-1 alleviates inflammatory responses and colon injury by inhibiting the JAK/STAT3 signaling pathway. PROTAC JAK1/2 degrader-1 can be used for the research of inflammatory bowel disease .
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