1 Result for "

ITZ-1

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "ITZ-1" in MCE Product Catalog:

Cat. No.: HY-120505
CAS No.: 1180532-17-5
Target:  

ERK p38 MAPK

Research Areas:  

Inflammation/Immunology

ITZ-1 is an orally active and selective extracellular signal-regulated kinase (ERK)-mitogen-activated protein kinase (MAPK) pathway inhibitor with an IC50 of 0.51 μM for inhibiting interleukin-1β (IL-1β)-induced matrix metalloproteinase-13 (MMP-13) production. ITZ-1 reduces MMP-13 expression and suppresses nitric oxide (NO)-induced chondrocyte apoptosi. ITZ-1 is promising for research of osteoarticular diseases [1].
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