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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1 Result for "
JS207
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "JS207" in MCE Product Catalog:
製品番号: HY-P992548
Target:
研究分野:
JS207 is a humanized IgG4-specific antibody targeting PD-1 and VEGFA . JS207 can block PD-1/PD-L1, PD-1/PD-L2, and VEGFA/VEGFR2 interactions, with IC50 values of 6.37 nM, 4.3 nM, and 3.35 nM, respectively. JS207 can relieve immunosuppression, promote T cell activation and IL-2/IFN-γ release, and induce PD-1 internalization. JS207 can inhibit VEGF-driven angiogenesis and has the property that VEGFA enhances PD-1 internalization. JS207 cross-reacts with cynomolgus monkey PD-1/VEGFA and rat/mouse VEGFA, but does not bind rat/mouse PD-1. JS207 shows antitumor efficacy in mouse colon cancer and melanoma models. JS207 can be used for research related to colon cancer and melanoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
