1 Result for "

KAI 407

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "KAI 407" in MCE Product Catalog:

Cat. No.: HY-18746
CAS No.: 1513879-18-9
Target:  

Parasite PI4K

Domaines de recherche:  

Infection

KAI-407 is an orally active inhibitor of Plasmodium PI4K kinase, which can broadly inhibit multiple stages of the parasite lifecycle. KAI-407 exhibits EC50s of for the blood stage of malignant Plasmodium of 81 nM; for the liver schizonts of P. yoelii of 88 nM; and IC50s for the liver schizonts and dormant bodies of P. cynomolgi of 0.64 μM and 0.69 μM respectively. KAI-407 can prevent Plasmodium berghei infection 100%. KAI-407 can be used for the study of vivax malaria .
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