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Isoforms Recommended: KDM4
Results for "

KDM4D

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-104048
    QC6352
    10+ Cited Publications

    		 Histone Demethylase Cancer
    QC6352 is an orally active KDM4 inhibitor with anti-tumor and anti-proliferative activity. QC6352 has in vivo inhibitory effects on PDX models of breast and colon cancer and reduces the number of chemoresistant cell populations. QC6352 inhibits KDM4 different isoforms with IC50s of 104 nM (KDM4A), 56 nM (KDM4B), 35 nM (KDM4C), and 104 nM (KDM4D), respectively. QC6352 has moderate inhibitory activity against KDM5 with an IC50 of 750 nM (KDM5B) .
    QC6352
  • HY-148807
    Zavondemstat

    QC8222 free base; TACH 101 free base

    		 Histone Demethylase Apoptosis Cancer
    Zavondemstat (QC8222 free base; TACH 101 free base) is an orally active pan-KDM4 inhibitor, with a IC50 ≤ 0.08 μM against human KDM4A-D and a Kᵢ of 0.52 μM against human KDM4C. Zavondemstat induces cell apoptosis, causes S-phase cell cycle arrest, reduces the population of tumor-initiating cells and inhibits cancer cell proliferation. Zavondemstat suppresses tumor growth and induces tumor regression in mouse xenograft models. Zavondemstat can be used for the research of various cancers including colorectal cancer, esophageal squamous cell carcinoma and triple-negative breast cancer .
    Zavondemstat
  • HY-101928
    KDM4D-IN-1
    2 Publications Verification

    		 Histone Demethylase Cancer
    KDM4D-IN-1 is a new histone lysine demethylase 4D (KDM4D) inhibitor with an IC50 value of 0.41±0.03 μM.
    KDM4D-IN-1
  • HY-RS07216
    KDM4D Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    KDM4D Human Pre-designed siRNA Set A contains three designed siRNAs for KDM4D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    KDM4D Human Pre-designed siRNA Set A
    KDM4D Human Pre-designed siRNA Set A
  • HY-RS20046
    Kdm4d Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Kdm4d Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kdm4d gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Kdm4d Mouse Pre-designed siRNA Set A
    Kdm4d Mouse Pre-designed siRNA Set A
  • HY-RS26549
    Kdm4d Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Kdm4d Rat Pre-designed siRNA Set A contains three designed siRNAs for Kdm4d gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Kdm4d Rat Pre-designed siRNA Set A
    Kdm4d Rat Pre-designed siRNA Set A
  • HY-148807B
    (S)-Zavondemstat

    (S)-QC8222 free base; (S)-TACH 101 free base

    		 Histone Demethylase Others
    (S)-Zavondemstat is the S-enantiomer of Zavondemstat (HY-148807). Zavondemstat is an inhibitor of histone lysine demethylase 4D (KDM4D) with antineoplastic activity [1] .
    (S)-Zavondemstat
  • HY-157408
    KDM4D-IN-3

    		Histone Demethylase Others
    KDM4D-IN-3 (compound 1) is a small-molecule epigenetic inhibitor target at KDM4D with an IC50 value of 4.8 μM .
    KDM4D-IN-3
  • HY-173135
    PROTAC KDM4 degrader-1

    		PROTACs Histone Demethylase Apoptosis Cancer
    PROTAC KDM4 degrader-1 is a KDM4 PROTAC degrader that degrades KDM4A-C with DC50 values of 37.53, 39.93, and 49.41 nM, respectively, while sparing KDM4D. PROTAC KDM4 degrader-1 induces cell cycle arrest, apoptosis and antiproliferative activity in esophageal cancer cells. PROTAC KDM4 degrader-1 can be used for the research of esophageal cancer .
    PROTAC KDM4 degrader-1
  • HY-101928R
    KDM4D-IN-1 (Standard)

    		Reference Standards Histone Demethylase Cancer
    KDM4D-IN-1 (Standard) is the analytical standard of KDM4D-IN-1 (HY-101928). This product is intended for research and analytical applications. KDM4D-IN-1 is a new histone lysine demethylase 4D (KDM4D) inhibitor with an IC50 value of 0.41±0.03 μM.
    KDM4D-IN-1 (Standard)
  • HY-104048R
    QC6352 (Standard)

    		Reference Standards Histone Demethylase Cancer
    QC6352 (Standard) is the analytical standard of QC6352 (HY-104048). This product is intended for research and analytical applications. QC6352 is an orally active KDM4 inhibitor with anti-tumor and anti-proliferative activity. QC6352 has in vivo inhibitory effects on PDX models of breast and colon cancer and reduces the number of chemoresistant cell populations. QC6352 inhibits KDM4 different isoforms with IC50s of 104 nM (KDM4A), 56 nM (KDM4B), 35 nM (KDM4C), and 104 nM (KDM4D), respectively. QC6352 has moderate inhibitory activity against KDM5 with an IC50 of 750 nM (KDM5B) .
    QC6352 (Standard)

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