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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
Kdm6b
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "Kdm6b" in MCE Product Catalog:
65
65 Publications Verification
Target:
Research Areas:
GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK J4 is a cell permeable proagent of GSK-J1 . GSK-J4 induces endoplasmic reticulum stress-related apoptosis .
65
65 Publications Verification
Target:
Research Areas:
GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1 .
17
17 Cited Publications
Target:
Research Areas:
GSK-J1, a chemical probe, is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC50 of 60 nM towards KDM6B.
17
17 Cited Publications
Target:
Research Areas:
GSK-J1 lithium salt is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC50 of 60 nM towards KDM6B.
16
Target:
Research Areas:
IOX1, a chemical probe, is a potent broad‐spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. IOX1 inhibits KDM4C, KDM4E, KDM2A, KDM3A and KDM6B with IC50 values of 0.6 μM, 2.3 μM, 1.8 μM, 0.1 μM and 1.4 μM, respectively . IOX1 also inhibits ALKBH5 .
5
4
4 Cited Publications
Target:
Research Areas:
GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A.
1
1 Cited Publications
Target:
Research Areas:
YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM. YUKA1 has less inhibitory active on KDM5C (IC50 = 7.12 μM) and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 can increase H3K4me3 levels and inhibit cell proliferation. YUKA1 can be used for the research of cancer, such as lung and breast cancers .
1
1 Cited Publications
Cat. No.: HY-N6896
CAS No.: 40788-84-9
Category:
other families Flavonoids Flavones Phenols Polyphenols Plants Disease Research Fields Cancer
Target:
Cat. No.: HY-RS07223
Target:
Research Areas:
KDM6B Human Pre-designed siRNA Set A contains three designed siRNAs for KDM6B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17203
Target:
Research Areas:
Kdm6b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kdm6b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23655
Target:
Research Areas:
Kdm6b Rat Pre-designed siRNA Set A contains three designed siRNAs for Kdm6b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-15648FR
CAS No.: 1797983-09-5
Target:
Research Areas:
GSK-J4 (hydrochloride) (Standard) is the analytical standard of GSK-J4 (hydrochloride). This product is intended for research and analytical applications. GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1 .
Cat. No.: HY-15648BR
CAS No.: 1373423-53-0
Target:
Research Areas:
GSK-J4 (Standard) is the analytical standard of GSK-J4. This product is intended for research and analytical applications. GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK J4 is a cell permeable proagent of GSK-J1 . GSK-J4 induces endoplasmic reticulum stress-related apoptosis .
Cat. No.: HY-15648G
CAS No.: 1797832-71-3
Target:
Research Areas:
GSK-J1 sodium is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC50 value of 60 nM towards KDM6B .
Cat. No.: HY-N2259R
CAS No.: 19431-84-6
Synonyms: (+)-Curcumenol (Standard)
Cat. No.: HY-15648I
CAS No.: 2108665-15-0
Target:
Research Areas:
GSK-J2 sodium is the sodium form of GSK-J2 (HY-15648A). GSK-J2 is an isomer of GSK-J1, and does not have any specific activity. GSK-J1 (HY-15648) is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A .
Cat. No.: HY-N6896R
CAS No.: 40788-84-9
Category:
other families Flavonoids Flavones Phenols Polyphenols Plants
Cat. No.: HY-P702082
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Kdm6b; Lysine (K)-Specific Demethylase 6b; Prev. JMJD3; Lysine-Specific Demethylase 6b; KIAA0346; [Histone H3]-Trimethyl-L-Lysine(27) Demethylase; Jumonji Domain Containing 3, Histone Lysine Demethylase; Jumonji Domain Containing 3; [Histone H3]-Trimethyl
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702083
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Kdm6b; Lysine (K)-Specific Demethylase 6b; Prev. JMJD3; Lysine-Specific Demethylase 6b; KIAA0346; [Histone H3]-Trimethyl-L-Lysine(27) Demethylase; Jumonji Domain Containing 3, Histone Lysine Demethylase; Jumonji Domain Containing 3; [Histone H3]-Trimethyl
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
