5852-78-8
5852-78-8
Chemical Structure
IOX1
- CAS No.: 5852-78-8
- Formula:C10H7NO3
- Molecular Weight:189.17
IUPAC Name: 8-hydroxyquinoline-5-carboxylic acid
InChIKey: JGRPKOGHYBAVMW-UHFFFAOYSA-N
SMILES: O=C(C1=C2C=CC=NC2=C(O)C=C1)O
Biological Activity: IOX1, a chemical probe, is a potent broad‐spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. IOX1 inhibits KDM4C, KDM4E, KDM2A, KDM3A and KDM6B with IC50 values of 0.6 μM, 2.3 μM, 1.8 μM, 0.1 μM and 1.4 μM, respectively[1][2]. IOX1 also inhibits ALKBH5[3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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IOX1 | 99.89% | IOX1, a chemical probe, is a potent broad‐spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. IOX1 inhibits KDM4C, KDM4E, KDM2A, KDM3A and KDM6B with IC50 values of 0.6 μM, 2.3 μM, 1.8 μM, 0.1 μM and 1.4 μM, respectively. IOX1 also inhibits ALKBH5. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.87
HY-W067427BAY32-5915 -
Similarity Score 0.87
HY-W0040295-Quinolinecarboxylic acid -
Similarity Score 0.87
HY-Y00574-Quinolinecarboxylic acid -
Similarity Score 0.86
HY-W007371Quinoline-8-carboxylic acid -
Similarity Score 0.85
HY-W0221647-Bromoquinoline-4-carboxylic acid -
Similarity Score 0.84
HY-100806RKynurenic acid (Standard) -
Similarity Score 0.84
HY-W0161031-Hydroxy-2-naphthoic acid -
Similarity Score 0.83
HY-W016794NSC3852 -
Similarity Score 0.83
HY-N7354RQuininic acid (Standard) -
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References
- [1]. Schiller R, et al. A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. ChemMedChem. 2014 Mar;9(3):566-71. [Content Brief]
- [2]. Hu Q, et al. IOX1, a JMJD2A inhibitor, suppresses the proliferation and migration of vascular smooth muscle cells induced by angiotensin II by regulating the expression of cell cycle-related proteins. Int J Mol Med. 2016 Jan;37(1):189-96. [Content Brief]
- [3]. Li F, et al. A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5. Biomol Screen. 2016 Mar;21(3):290-7. [Content Brief]
