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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
MI-3
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "MI-3" in MCE Product Catalog:
1
1 Cited Publications
Synonyms: Menin-MLL inhibitor 3
Target:
Research Areas:
MI-3 (Menin-MLL inhibitor 3) is a potent and high affinity menin-MLL inhibitor with an IC50 of 648 nM and a Kd of 201 nM .
Cat. No.: HY-162538
CAS No.: 3053823-69-8
Research Areas:
LC-MI-3 is an orally active IRAK4 degrader with an IC50 of 57.2 nM and high selectivity among human protein kinases [2].LC-MI-3 eliminates IRAK4 kinase and scaffolding functions via the cereblon E3 ubiquitin ligase and ubiquitin-proteasome systems [2].LC-MI-3 inhibits downstream nuclear factor-κB and IRAK4-mediated inflammatory signaling pathways [2].LC-MI-3 exerts anti-inflammatory activity in lipopolysaccharide-, Escherichia coli-, TLR4-, and TLR7-induced inflammatory models [2].LC-MI-3 can be used for the research of acute lung injury, sepsis, psoriasis, and inflammatory diseases [3].
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
