1 Result for "

MP-RM-1

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "MP-RM-1" in MCE Product Catalog:

MP-RM-1
MP-RM-1
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Cat. No.: HY-P991243

Target:  

EGFR Akt

Research Areas:  

Cancer

MP-RM-1 is an antibody-based, non-competitive ErbB-3 inhibitor with a Kd value of 32.7 nM. MP-RM-1 inhibits both ligand-dependent and ligand-independent ErbB-3 activation, blocks ErbB-2/ErbB-3 heterodimerization, induces ErbB-3 internalization and degradation, and suppresses the phosphorylation of downstream Akt. MP-RM-1 exerts its antagonistic effect through a non-competitive mechanism. MP-RM-1 inhibits tumor growth in melanoma and prostate cancer xenograft models in nude mice and reduces the proliferative activity of tumor cells [1].
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