10 Results for "

Methotrexate-d3

" in MedChemExpress (MCE) Product Catalog:
Products (10)

10 Results for "Methotrexate-d3" in MCE Product Catalog:

Cat. No.: HY-14519S
CAS No.: 432545-63-6
Methotrexate-d3 is the deuterated-labeled Methotrexate (HY-14519). Methotrexate (Amethopterin; CL14377; WR19039) is an orally active antifolate (Antifolate). Methotrexate inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer [3] .
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Cat. No.: HY-W743645
Methotrexate-d3 Heptaglutamate Trifluoroacetate is the deuterium labeled Methotrexate Heptaglutamate Trifluoroacetate.
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Cat. No.: HY-W745177
Methotrexate-d3 Pentaglutamate Trifluoroacetate is the deuterium labeled Methotrexate Pentaglutamate Trifluoroacetate.
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Cat. No.: HY-W769792
Methotrexate-d3 Diglutamate TFA Sulfate is the deuterium labeled Methotrexate Diglutamate TFA Sulfate.
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Cat. No.: HY-W654227
7-Hydroxy methotrexate-d3 (ammonium salt) is deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis [3].
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Cat. No.: HY-14519S1
Purity:  99.69%
Methotrexate-d3 diammonium is the deuterated-labeled Methotrexate (HY-14519). Methotrexate (Amethopterin; CL14377; WR19039) is an orally active antifolate (Antifolate). Methotrexate inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer [3] .
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Cat. No.: HY-W745173
Methotrexate-d3 Triglutamate Trifluoroacetate is the deuterium labeled Methotrexate Triglutamate Trifluoroacetate.
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Cat. No.: HY-14519CS
CAS No.: 2470329-38-3
(R)-Methotrexate-d3 is the deuterium labeled (R)-Methotrexate .
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Cat. No.: HY-121151S
Synonyms: (±)-Amethopterin-d3; (±)-CL14377-d3; (±)-WR19039-d3
(±)-Methotrexate-d3 ((±)-Amethopterin-d3; (±)-CL14377-d3; (±)-WR19039-d3) is the deuterated-labeled (±)-Methotrexate (HY-121151). (±)-Methotrexate is the racemate of Methotrexate (HY-14519). Methotrexate is an orally active antifolate (Antifolate). Methotrexate inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer [3] .
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Cat. No.: HY-W743130
DL-Methotrexate-d3 Dipotassium Salt is the deuterium labeled DL-Methotrexate Dipotassium Salt.
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