41 Results for "

N-terminal fragment

" in MedChemExpress (MCE) Product Catalog:
Products (41)

41 Results for "N-terminal fragment" in MCE Product Catalog:

4
4 Cited Publications
Cat. No.: HY-P0176
CAS No.: 127317-03-7
Synonyms: PACAP 1-27
Target:  

PACAP Receptor

PACAP (1-27), human, ovine, rat (PACAP 1-27) is the N-terminal fragment of PACAP-38, and is a potent PACAP receptor agonist with IC50s of 3 nM, 2 nM and 5 nM for rat PAC1, rat VPAC1 and human VPAC2, respectively .
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4
4 Cited Publications
Cat. No.: HY-P0176A
Synonyms: PACAP 1-27 TFA
Target:  

PACAP Receptor

PACAP (1-27), human, ovine, rat TFA (PACAP 1-27 TFA) is the N-terminal fragment of PACAP-38, and is a potent PACAP receptor agonist with IC50s of 3 nM, 2 nM and 5 nM for rat PAC1, rat VPAC1 and human VPAC2, respectively .
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1
1 Cited Publications
Cat. No.: HY-P99777
CAS No.: 2131089-46-6
Synonyms: TTI-621

Target:  

CD47

Research Areas:  

Cancer

Ontorpacept (TTI-621) is a soluble fusion protein that consists of the human SIRPα N-terminal (1-118) linked to the Fc region of human IgG1. The N-terminal (1-118)-fragment of ontorpacept is a binding domain for CD47 which is an inhibitor of phagocytosis by macrophages. Ontorpacept is a CD47-blocking checkpoint inhibitor with antitumor activity .
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Cat. No.: HY-E70563
CAS No.: 91116-93-7
Research Areas:  

Others

Endoproteinase Lys-N (MS grade) is a protease that specifically hydrolyzes the N-terminal peptide bond of lysine fragments .
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Cat. No.: HY-18711A
CAS No.: 1174161-86-4
Synonyms: Metatinib anhydrous; c-Met inhibitor 2
Research Areas:  

Cancer

SCR-1481B1 (Metatinib anhydrous; c-Met inhibitor 2) is an inhibitor of the N-terminal fragment of Gasdermin D (GSDMD), with an IC50 of 1.04 μM and a Ka of 0.42 μM in mice. SCR-1481B1 effectively blocks GSDMD-NT oligomerization and pore formation, inhibits GSDMD-mediated pyroptosis (Pyroptosis), preserves mitochondrial integrity, and reduces proinflammatory cytokine secretion. SCR-1481B1 also inhibits angiogenesis, exerts GSDMD-independent antitumor effects, and enhances the infiltration of antitumor immune cells. SCR-1481B1 is also an inhibitor targeting to c-MET and VEGFR2, can be used in studies related to melanoma and sepsis .
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Cat. No.: HY-P4371
CAS No.: 177942-21-1
Research Areas:  

Inflammation/Immunology

Hel 13-5 is a monomeric, lipophilic, basic amphipathic α-helical synthetic peptide composed of 18 amino acid residues. Hel 13-5 is designed as a substitute for proteins in artificial pulmonary surfactants, and it mimics the interaction between the N-terminal fragment of human pulmonary surfactant protein B and lipids. Hel 13-5 can bind to phospholipids for the development of pulmonary surfactant model systems. Hel 13-5 can be used in studies related to respiratory distress syndrome .
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Cat. No.: HY-P1499
CAS No.: 79243-10-0
Target:  

Somatostatin Receptor

Research Areas:  

Neurological Disease

Somatostatin-28 (1-14) is an N-terminal fragment of the neuropeptide somatostatin-28.
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Cat. No.: HY-P2677
CAS No.: 89911-65-9
Research Areas:  

Metabolic Disease

CCK (26-31) (sulfated) is the N-terminal fragment of CCK, a peptide hormone found in the gut and brain that stimulates digestion, regulates satiety, and is associated with anxiety .
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Cat. No.: HY-P1425
CAS No.: 313664-40-3
Target:  

Ser/Thr Protease

Research Areas:  

Neurological Disease

(Z-LL)2 ketone is an inhibitor of ketone with an IC50 value of 50 nM. (Z-LL)2 ketone inhibits processing of thep-Prlsignal peptide .
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Cat. No.: HY-P4004
CAS No.: 245443-51-0
PAR-4 (1-6) amide human is an N-terminal fragment of protease-activated receptor 4 (PAR4). PAR-4 (1-6) amide human induce platelet aggregation .
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Cat. No.: HY-P4933
CAS No.: 2022995-68-0
Synonyms: Tau-F protein (255-314)
Target:  

Tau Protein

Research Areas:  

Neurological Disease

Tau Peptide (255-314) (Repeat 2 Domain) (human) (Tau-F protein (255-314)) is a polypeptide. Tau Peptide (255-314) (human) is the 255-314 fragment of Tau-F (also known as Tau-4, the 2N4 isoform), a major isoform of the Tau protein. Tau Peptide (255-314) (human) contains two core driving sequences for Tau aggregation, namely PHF6* (275-280, VQIINK) and PHF6 (306-311, VQIVYK), and spans the C-terminal half of repeat domain R1, the entire repeat domain R2, and the N-terminal half of repeat domain R3 within the microtubule-binding region (MTBR).
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Cat. No.: HY-P1922
CAS No.: 799841-81-9
Target:  

Melanocortin Receptor

Research Areas:  

Endocrinology

γ-2-MSH (41-58), amide is derived from γ-2-MSH. γ-2-MSH is a twelve amino acid peptide that is derived from the N-terminal fragment of proopiomelanocortin (POMC) and contains the His-Phe-Arg-Trp motif common to all melanocortin endogenous agonist ligands .
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Cat. No.: HY-P10506
CAS No.: 146877-90-9
Target:  

JNK

Research Areas:  

Neurological Disease

CMX-8933 is an octapeptide fragment of the goldfish brain neurotrophic factor ependymin. CMX-8933 increases the enzymatic activity of c-Jun N-terminal kinase (JNK), increases the phosphorylation of JNK and c-Jun proteins, and increases the cellular levels of c-Jun and c-Fos mRNA. CMX-8933 can be used to study the role of ependymin in neuroplasticity, learning, memory formation, and neural regeneration .
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Cat. No.: HY-P3897
CAS No.: 198276-46-9
Target:  

Somatostatin Receptor

Research Areas:  

Neurological Disease

[Tyr12] Somatostatin 28 (1-14) is an analogue of Somatostatin-28 (1-14) (HY-P1499). Somatostatin-28 (1-14) is an N-terminal fragment of the neuropeptide somatostatin-28 .
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Cat. No.: HY-P4371A
Target:  

Inhibitory Antibodies

Research Areas:  

Others

Hel 13-5 TFA is a monomeric synthetic peptide based on the N-terminal fragment of human SP-B. Hel 13-5 TFA is mainly α-helical and consists of 13 hydrophobic amino acid residues and 5 hydrophilic amino acid residues. Hel 13-5 TFA can be combined with phospholipids for the development of a model system for pulmonary surfactant .
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Cat. No.: HY-P1319
CAS No.: 178249-42-8
Target:  

Opioid Receptor

Research Areas:  

Inflammation/Immunology

Nociceptin (1-7) is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) is a potent ORL1 (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia in vivo .
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Cat. No.: HY-P4657
CAS No.: 96827-07-5
Target:  

Inhibitory Antibodies

Research Areas:  

Endocrinology

Human Growth Hormone (1-43) is an N-terminal fragment of human growth hormone with specific and pronounced insulin-like activity. Human Growth Hormone (1-43) can be used to study the function and metabolic pathways of growth hormone, a potential obesity-related factor .
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Cat. No.: HY-P5748
CAS No.: 170917-43-8
Target:  

ADC Payloads

Research Areas:  

Others

Bac5(1-25) is an N-terminal fragment of the bovine proline-rich antimicrobial peptide Bac5 .
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Cat. No.: HY-P4701
CAS No.: 112955-31-4
Synonyms: Human PTHrP-(1-34)NH2
Target:  

PTHR

Research Areas:  

Metabolic Disease

pTH-Related Protein (1-34) amide (human, mouse, rat) (Human PTHrP-(1-34)NH2) is a N-terminal fragments of PTHrP. pTH-Related Protein (1-34) amide (human, mouse, rat) induces hypercalcemia, and can be used for research of humoral hypercalcaemia of malignancy .
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Cat. No.: HY-P3692
CAS No.: 1815618-15-5
Research Areas:  

Neurological Disease

CART (55-76), rat is a neuropeptide (55-76 residues of the CART peptide) and constitutes the N-terminal fragments of CART (55-102). CART (55-76), rat is a rat satiety factor with potent appetite-suppressing activity and is closely associated with leptin and neuropeptide Y. CART (55-76), rat can induce anxiety and stress-related behavior .
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