3 Results for "

NSC90469

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "NSC90469" in MCE Product Catalog:

NSC 90469
NSC 90469
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Cat. No.: HY-114557
CAS No.: 1041-01-6
Purity:  99.38%
Synonyms: 3,5-Diiodo-L-thyronine
Category:  

Monophenols Ketones, Aldehydes, Acids Metabolic Disease Phenols Endogenous metabolite Disease Research Fields

Target:  

JNK NF-κB Sirtuin PGC-1α COX TGF-β Receptor Collagen

NSC 90469 (3,5-Diiodo-L-thyronine) is an orally active thyroid hormone derivative. NSC 90469 inhibits JNK phosphorylation and NF-κB acetylation, blocks SIRT1 protein expression, induces elevated PGC-1α levels, and stimulates COX activity. NSC 90469 enhances UCP1-mediated thermogenesis, increases hepatic Dio1 activity, inhibits TSH levels and hypothalamic-pituitary-thyroid axis function, enhances lipid metabolism, and regulates energy metabolism via the mitochondrial pathway. NSC 90469 prevents blood glucose reduction, reduces urinary albumin excretion, inhibits renal matrix expansion, decreases TGF-β1 expression, and reduces renal fibronectin and type Ⅳ collagen deposition. NSC 90469 also increases energy expenditure and prevents diet-induced overweight. NSC 90469 can be used in studies related to diabetic nephropathy, hypothyroidism, non-alcoholic fatty liver disease, and diet-induced obesity .
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NSC 90469 (Standard)
NSC 90469 (Standard)
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Cat. No.: HY-114557R
CAS No.: 1041-01-6
Synonyms: 3,5-Diiodo-L-thyronine (Standard)
Category:  

Monophenols Ketones, Aldehydes, Acids Phenols Endogenous metabolite

Target:  

Reference Standards Endogenous Metabolite

NSC 90469 (Standard) is the analytical standard of NSC 90469. This product is intended for research and analytical applications. NSC 90469 (3,5-Diiodo-L-thyronine) is an orally active thyroid hormone derivative. NSC 90469 inhibits JNK phosphorylation and NF-κB acetylation, blocks SIRT1 protein expression, induces elevated PGC-1α levels, and stimulates COX activity. NSC 90469 enhances UCP1-mediated thermogenesis, increases hepatic Dio1 activity, inhibits TSH levels and hypothalamic-pituitary-thyroid axis function, enhances lipid metabolism, and regulates energy metabolism via the mitochondrial pathway. NSC 90469 prevents blood glucose reduction, reduces urinary albumin excretion, inhibits renal matrix expansion, decreases TGF-β1 expression, and reduces renal fibronectin and type Ⅳ collagen deposition. NSC 90469 also increases energy expenditure and prevents diet-induced overweight. NSC 90469 can be used in studies related to diabetic nephropathy, hypothyroidism, non-alcoholic fatty liver disease, and diet-induced obesity .
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NSC 90469-d4
NSC 90469-d4
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Cat. No.: HY-114557S
Synonyms: 3,5-Diiodo-L-thyronine-d4
NSC 90469-d4 (3,5-Diiodo-L-thyronine-d4) is the deuterium labeled NSC 90469 (HY-114557). NSC 90469 is an endogenous metabolite.
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