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Nandinine

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-182558
    Nandinine

    		Drug Derivative AMPK IKK NF-κB Metabolic Disease
    Nandinine is an orally active derivative of Berberine (HY-N0716). Nandinine enhances AMPK activity, inhibits the activation of IKKβ/NF-κB, and regulates the phosphorylation of IRS-1. Nandinine reverses the abnormal production of adipokines, promotes insulin-mediated glucose uptake, and alleviates insulin resistance. Nandinine improves glucose tolerance and increases the insulin sensitivity index in mice. Nandinine can be used in studies related to insulin resistance .
    Nandinine
  • HY-E71128
    (S)-Nandinine synthase

    		Biochemical Assay Reagents Others
    (S)-Nandinine synthase (EC 1.14.21.12) is a cytochrome P-450 heme-thiolate enzyme catalysing an oxidative reaction that does not incorporate oxygen into the product. Forms the methylenedioxy bridge of the protoberberine alkaloid (S)-Nandinine by the oxidative ring closure of adjacent phenolic and methoxy groups of (S)-Scoulerine.
    (S)-Nandinine synthase

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