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Pathways Recommended:	Vitamin D Related/Nuclear Receptor Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

Nuclear Factor of activated T Cells (NFAT)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Nuclear Factor of activated T Cells (NFAT) (12) AMPK (1) Apoptosis (1) CD28 (1) CD3 (1) CRM1 (1) Endogenous Metabolite (1) Interleukin Related (2) Phosphodiesterase (PDE) (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (11) Metabolic Disease (3) Neurological Disease (1)

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Antibodies

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) Orphan Nuclear Receptor NF-κB TREM receptor Nuclear Hormone Receptor 4A/NR4A

Art. -Nr.	Produktname	Target	Forschungsgebiete	Chemical Structure

HY-P1430

11R-VIVIT 5+ Cited Publications Cell permeable NFAT inhibitor	Nuclear Factor of activated T Cells (NFAT)	Metabolic Disease
11R-VIVIT is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT can be used for the research of podocyte and diabetic nephropathy .

HY-112126

KRN5 2 Publications Verification	Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
KRN5, a derivative of KRN2, is an oral active **Nuclear factor of activated T cells 5 (NFAT5) suppressor, with an IC₅₀** of 750 nM. KRN5 has potential to treat NFAT5-mediated Chronic Arthritis .

HY-112125

KRN2 4 Publications Verification	Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
KRN2 is a selective inhibitor of **nuclear factor of activated T cells (NFAT5), with an IC₅₀** of 100 nM. KRN2 has potential to treat NFAT5-mediated Chronic Arthritis .

HY-112125A

KRN2 bromide 4 Publications Verification	Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
KRN2 (bromide) is a selective inhibitor of **nuclear factor of activated T cells (NFAT5), with an IC₅₀** of 0.1 μM.

HY-N4053

Heraclenin	Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
Heraclenin, a natural furanocoumarin, significantly inhibits T cell receptor-mediated proliferation in human primary T cells in a concentration-dependent manner by targeting nuclear factor of activated T-cells (NFAT) .

HY-136427

KRM-III	Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
KRM-III is a potent and orally active *T-cell* antigen receptor (TCR) inhibitor. KRM-III inhibits TCR*- and phorbol myristate acetate/ionomycin-induced activation* of nuclear factor of activated T cells (NFAT) and T-cell proliferation with an IC₅₀ of ~5 μM. Anti-inflammatory activity .

HY-P1430A

11R-VIVIT TFA 5+ Cited Publications Cell permeable NFAT inhibitor TFA	Nuclear Factor of activated T Cells (NFAT)	Metabolic Disease
11R-VIVIT TFA is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT TFA can be used for the research of podocyte and diabetic nephropathy .

HY-139464

Q134R	Nuclear Factor of activated T Cells (NFAT)	Neurological Disease
Q134R, a neuroprotective hydroxyquinoline derivative that suppresses **nuclear factor of activated T cell (NFAT)** signaling. Q134R can across blood-brain barrier. Q134R has the potential for Alzheimer's disease (AD) and aging-related disorders research .

HY-N4171

Dihydrocucurbitacin B	Apoptosis	Inflammation/Immunology
Dihydrocucurbitacin B, a triterpene isolated from Cayaponia tayuya roots, inhibits nuclear factor of activated T cells (NFAT), induces cell cycle arrested in the G0 phase, and inhibits delayed type hypersensitivity .

HY-174132

CW8001	CRM1	Inflammation/Immunology
CW8001 is a covalent XPO1 (Exportin-1) inhibitor with an EC₅₀ value of 1 nM for inhibiting T cell activation. CW8001 prevents nuclear localization of NFAT transcription factors, suppressing expression of inflammatory cytokines like IL-2. CW8001 is promising for research of T cell-driven immune diseases such as graft-versus-host disease (GVHD) .

HY-19486

UR-1505	Nuclear Factor of activated T Cells (NFAT) CD3 CD28 Interleukin Related	Inflammation/Immunology
UR-1505 is a **nuclear factor of activated T cells (NF-AT) inhibitor. UR-1505 can suppress CD3/CD28** induced T cell proliferation, increase p27 ^KIP levels, and induce G1/S cell cycle arrest. UR-1505 can also inhibit the production of IL-5 and IFN-γ in activated T cells. UR-1505 has immunomodulatory properties and can be used in the study of atopic dermatitis .

HY-132243

NFAT Inhibitor-3	Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
NFAT Inhibitor-3 (Compound 10) is a factor nuclear factor of activated T cells (NFAT) inhibitor. NFAT Inhibitor-3 inhibits IL-2 production. NFAT Inhibitor-3 binds in a sequence-selective manner directly to DNA. NFAT Inhibitor-3 can be used for the research of transcription factor dysregulation .

HY-126754

Archangelicin	Nuclear Factor of activated T Cells (NFAT) Phosphodiesterase (PDE)	Inflammation/Immunology Cancer
Archangelicin is an inhibitor for cAMP-phosphodiesterase (cAMP-PDE) with IC₅₀ >400 μM. Archangelicin inhibits nuclear factor of activated T cell (NFAT) with IC₅₀ of 9 μM. Archangelicin exhibits antitumor and anti-inflammatory .

HY-N16431

NFAT-133	AMPK Nuclear Factor of activated T Cells (NFAT) Interleukin Related Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
NFAT-133 is an aromatic polyketide with immunosuppressive and antidiabetic activity. NFAT-133 activates the AMPK pathway, promoting glucose uptake in L6 muscle fibers, thereby resisting diabetes. NFAT-133 inhibits the transcriptional activity of activated T-cell nuclear factor (NFAT), thereby suppressing the expression of IL-2 and the proliferation of T cells, demonstrating an immunosuppressive effect. NFAT-133 does not exhibit antibacterial activity or cytotoxicity, but it can weaken the production of NO in RAW264.7 cells induced by Lipopolysaccharide (LPS) (HY-D1056) .

Art. -Nr.	Produktname	Target	Research Area

HY-P1430

11R-VIVIT 5+ Cited Publications Cell permeable NFAT inhibitor	Nuclear Factor of activated T Cells (NFAT)	Metabolic Disease
11R-VIVIT is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT can be used for the research of podocyte and diabetic nephropathy .

HY-P1430A

11R-VIVIT TFA 5+ Cited Publications Cell permeable NFAT inhibitor TFA	Nuclear Factor of activated T Cells (NFAT)	Metabolic Disease
11R-VIVIT TFA is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT TFA can be used for the research of podocyte and diabetic nephropathy .

Heraclenin	Classification of Application Fields Coumarins Phenylpropanoids Plants Umbelliferae Seriphidium transiliense Inflammation/Immunology Disease Research Fields Source Classification	Nuclear Factor of activated T Cells (NFAT)
Heraclenin, a natural furanocoumarin, significantly inhibits T cell receptor-mediated proliferation in human primary T cells in a concentration-dependent manner by targeting nuclear factor of activated T-cells (NFAT) .

Dihydrocucurbitacin B	Triterpenes other families Classification of Application Fields Terpenoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis
Dihydrocucurbitacin B, a triterpene isolated from Cayaponia tayuya roots, inhibits nuclear factor of activated T cells (NFAT), induces cell cycle arrested in the G0 phase, and inhibits delayed type hypersensitivity .

Archangelicin	Coumarins Phenylpropanoids Artemisia kotuchovii Kupr. Umbelliferae Plants Source Classification	Nuclear Factor of activated T Cells (NFAT) Phosphodiesterase (PDE)
Archangelicin is an inhibitor for cAMP-phosphodiesterase (cAMP-PDE) with IC₅₀ >400 μM. Archangelicin inhibits nuclear factor of activated T cell (NFAT) with IC₅₀ of 9 μM. Archangelicin exhibits antitumor and anti-inflammatory .

NFAT-133	Natürliche Produkte Microorganisms Source Classification	AMPK Nuclear Factor of activated T Cells (NFAT) Interleukin Related Endogenous Metabolite
NFAT-133 is an aromatic polyketide with immunosuppressive and antidiabetic activity. NFAT-133 activates the AMPK pathway, promoting glucose uptake in L6 muscle fibers, thereby resisting diabetes. NFAT-133 inhibits the transcriptional activity of activated T-cell nuclear factor (NFAT), thereby suppressing the expression of IL-2 and the proliferation of T cells, demonstrating an immunosuppressive effect. NFAT-133 does not exhibit antibacterial activity or cytotoxicity, but it can weaken the production of NO in RAW264.7 cells induced by Lipopolysaccharide (LPS) (HY-D1056) .

Host:	Mouse (2) Rabbit (3)
Reactivity:	Human (4) mouse (1) rat (1) Rat (1) Mouse (3) human (1)
Application:	IHC-P (2) ICC/IF (1) IF-Tissue (1) IP (1) WB (5) FC (1) ELISA (1)
Isotype:	IgG (3) IgG1 (1)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (3) Recombinant (2)
Modification:	Phosphorylated (1) Unmodified (3)

Art. -Nr.	Compare	Produktname	Application	Reactivity	Image

HY-P80243

	NFAT2 Antibody (YA270) cytoplasmic 1 antibody; MGC138448 antibody; NF ATc antibody; NF ATc1 antibody; NF-ATc antibody; NF-ATc1 antibody; NF-ATc1.2 antibody; NFAC1_HUMAN antibody; NFAT 2 antibody; NFAT transcription complex cytosolic component antibody; NFATC 1 antibody; NFATc antibody; NFATc1 antibody; Nuclear Factor of activated T Cells cytoplasmic 1 antibody; Nuclear Factor of activated T Cells cytoplasmic calcineurin dependent 1 antibody; Nuclear Factor of activated T Cells cytosolic component 1 antibody; Nuclear Factor of activated T-Cells 'c' antibody; Nuclear Factor of activated T-Cells antibody	WB, IHC-P, FC	Human
	NFAT2 Antibody (YA270) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NFAT2.

HY-P85699

	NFAT5 Antibody (YA5391) Nuclear Factor of activated T-Cells 5; NF-AT5; T-cell transcription Factor NFAT5; Tonicity-responsive enhancer-binding protein; TonE-binding protein; TonEBP;	IHC-P, WB	Human, Mouse, Rat
	NFAT5 Antibody (YA5391) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NFAT5.

HY-P81644

	Phospho-NFAT2 (Ser237) Antibody (YA1389) NFATC1; NFAT2; NFATC; Nuclear Factor of activated T-Cells; cytoplasmic 1; NF-ATc1; NFATc1; NFAT transcription complex cytosolic component; NF-ATc; NFATc	WB	Human, Mouse
	Phospho-NFAT2 (Ser237) Antibody (YA1389) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-NFAT2 (Ser237).

HY-P81644A

	Phospho-NFAT2 (Ser237) Antibody (YA1389)(PBS only) NFATC1; NFAT2; NFATC; Nuclear Factor of activated T-Cells; cytoplasmic 1; NF-ATc1; NFATc1; NFAT transcription complex cytosolic component; NF-ATc; NFATc	WB	Human, Mouse
	Phospho-NFAT2 (Ser237) Antibody (YA1389) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-NFAT2 (Ser237).

HY-P89716

	NFATc2IP Antibody (YA9060) Nuclear Factor of activated T-Cells, cytoplasmic 2-interacting protein, NIP45, NFATC2-interacting protein, NFATC2 interacting protein, 45 kDa NFAT-interacting protein	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat
	NFATc2IP Antibody (YA9060) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NFATc2IP.

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Nuclear Factor of activated T Cells (NFAT)

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