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OAS1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (1) Caspase (1) HIV (1) IFNAR (1) MyD88 (1) Pyroptosis (1) Reactive Oxygen Species (ROS) (1) Small Interfering RNA (siRNA) (1) STING (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (1) Infection (1) Neurological Disease (1)
Oligonucleotides:	CpG ODNs (1) Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-160229

ssRNA40 sodium R-1075 sodium	Toll-like Receptor (TLR) MyD88 Caspase Reactive Oxygen Species (ROS) Autophagy Pyroptosis HIV	Infection Neurological Disease
ssRNA40 sodium (R-1075 sodium) is a single-stranded RNA40 derived from HIV-1. ssRNA40 sodium activates the TLR7, TLR8, TLR2, RIG-I, MDA5, MyD88, Caspase-3, *IRE1α, NLRP3* inflammasome and IRF7 signaling pathways. ssRNA40 sodium alters mRNA expression in neutrophils, induces pro-inflammatory cytokines, ROS, autophagy (autophagy), pyroptosis (pyroptosis), neuronal death, neurodegeneration, aggregate formation and NK cell activation. ssRNA40 sodium activates the expression of CD62L, CD11b, CD69, *MX1, OAS1, ATG7, LC3B* and *XBP1* in immune cell and neuronal populations. ssRNA40 sodium causes cortical neuron loss and axonal damage in mice in a TLR7-dependent manner. ssRNA40 sodium can be used in research on *HIV-1* infection, neurodegeneration, COVID-19 and HIV-associated neurological disorders ^[1] .

HY-162465

BDW568	STING IFNAR	Cancer
BDW568 is a selective STING ^A230 agonist with an EC₅₀ of 5.7 μM. BDW568 triggers the interferon signaling pathway and induces the expression of interferon-stimulated genes including *MX1* and *OAS1*. BDW568 is applicable for cancer-related research ^[1] .

HY-RS09727

OAS1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
OAS1 Human Pre-designed siRNA Set A contains three designed siRNAs for OAS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

OAS1 Human Pre-designed siRNA Set A OAS1 Human Pre-designed siRNA Set A

Cat. No.	Product Name		Classification

HY-160229

ssRNA40 sodium R-1075 sodium		CpG ODNs
ssRNA40 sodium (R-1075 sodium) is a single-stranded RNA40 derived from HIV-1. ssRNA40 sodium activates the TLR7, TLR8, TLR2, RIG-I, MDA5, MyD88, Caspase-3, *IRE1α, NLRP3* inflammasome and IRF7 signaling pathways. ssRNA40 sodium alters mRNA expression in neutrophils, induces pro-inflammatory cytokines, ROS, autophagy (autophagy), pyroptosis (pyroptosis), neuronal death, neurodegeneration, aggregate formation and NK cell activation. ssRNA40 sodium activates the expression of CD62L, CD11b, CD69, *MX1, OAS1, ATG7, LC3B* and *XBP1* in immune cell and neuronal populations. ssRNA40 sodium causes cortical neuron loss and axonal damage in mice in a TLR7-dependent manner. ssRNA40 sodium can be used in research on *HIV-1* infection, neurodegeneration, COVID-19 and HIV-associated neurological disorders ^[1] .

HY-RS09727

OAS1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
OAS1 Human Pre-designed siRNA Set A contains three designed siRNAs for OAS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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