5 Results for "

OGDH

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "OGDH" in MCE Product Catalog:

14
14 Cited Publications
Cat. No.: HY-12688A
CAS No.: 864167-45-3
Purity:  ≥98.0%
Succinyl phosphonate trisodium salt is a α-Ketoglutarate Dehydrogenase Complex (KGDHC) modulator with neuroprotective activity. Succinyl phosphonate trisodium salt protects this complex, reduces cellular succinyl-CoA concentration, downregulates protein succinylation levels, and inhibits the activity of the α-ketoglutarate dehydrogenase complex. Succinyl phosphonate trisodium salt corrects hypoxic or ethanol-induced behavioral impairments, modulates exploratory behavior and emotional stress responses, and improves hypoxia tolerance. Succinyl phosphonate trisodium salt reduces glutamate excitotoxicity, restores the activity of the α-ketoglutarate dehydrogenase complex, reverses the changes in glutamate dehydrogenase and glutamine synthetase activities induced by β-amyloid (Amyloid-β), modulates cognitive function, and prevents β-amyloid-induced neuronal damage. Succinyl phosphonate trisodium salt improves microglial senescence, alleviates neuroinflammation, reactive oxygen species (ROS) production, lipid peroxidation, and the expression of proinflammatory cytokines. Succinyl phosphonate trisodium salt can be used in the research of Alzheimer's disease, aging-related neuroinflammation, and Parkinson's disease .
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Cat. No.: HY-RS17494
Research Areas:  

Others

Ogdh Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ogdh gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS09758
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OGDH Human Pre-designed siRNA Set A contains three designed siRNAs for OGDH gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS23951
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Others

Ogdh Rat Pre-designed siRNA Set A contains three designed siRNAs for Ogdh gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P71567
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: OGDH; Kiaa4192; 2-oxoglutarate dehydrogenase; mitochondrial; EC 1.2.4.2; 2-oxoglutarate dehydrogenase complex component E1; OGDC-E1; Alpha-ketoglutarate dehydrogenase
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