1 Result for "

PAO-PDT

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "PAO-PDT" in MCE Product Catalog:

Cat. No.: HY-116032
CAS No.: 256348-71-7
Target:  

TrxR

Research Areas:  

Cancer

PAO-PDT is an organoarsenic inhibitor of thioredoxin reductase (TrxR), with an IC50 of 33 nM. PAO-PDT can bind to the C-terminal selenocysteine/cysteine pair of TrxR and convert the enzyme into an NADPH oxidase, which increases reactive oxygen species levels and impairs mitochondrial respiratory function, thereby inducing apoptosis in leukemia cells. PAO-PDT can be used for leukemia research .
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