256348-71-7
256348-71-7
Chemical Structure
PAO-PDT
- CAS No.: 256348-71-7
- Formula:C9H12AsNS2
- Molecular Weight:273.24
IUPAC Name: 4-(1,3,2-dithiarsinan-2-yl)aniline
InChIKey: WONBTYJJKXSAKA-UHFFFAOYSA-N
SMILES: S1[As](SCCC1)C2=CC=C(N)C=C2
Biological Activity: PAO-PDT is an organoarsenic inhibitor of thioredoxin reductase (TrxR), with an IC50 of 33 nM. PAO-PDT can bind to the C-terminal selenocysteine/cysteine pair of TrxR and convert the enzyme into an NADPH oxidase, which increases reactive oxygen species levels and impairs mitochondrial respiratory function, thereby inducing apoptosis in leukemia cells. PAO-PDT can be used for leukemia research[1][2][3][4].
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PAO-PDT | PAO-PDT is an organoarsenic inhibitor of thioredoxin reductase (TrxR), with an IC50 of 33 nM. PAO-PDT can bind to the C-terminal selenocysteine/cysteine pair of TrxR and convert the enzyme into an NADPH oxidase, which increases reactive oxygen species levels and impairs mitochondrial respiratory function, thereby inducing apoptosis in leukemia cells. PAO-PDT can be used for leukemia research. | |||||||||||||||||||||
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References
- [1]. Liu Y, et al. Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase. Journal of medicinal chemistry. 2014 Jun 26;57(12):5203-11. [Content Brief]
- [2]. Shi S, et al. Structure-Guided optimization of PAO-PDT yields TrxR inhibitors as potential anticancer agent. European journal of medicinal chemistry. 2026 Feb 05;303:118407. [Content Brief]
- [3]. Fan XY, et al. A mitochondria-targeted organic arsenical accelerates mitochondrial metabolic disorder and function injury. Bioorganic & medicinal chemistry. 2019 Mar 01;27(5):760-768.
- [4]. Song ZL, et al. Structural Modification of Aminophenylarsenoxides Generates Candidates for Leukemia Treatment Thioredoxin Reductase Inhibition. Journal of medicinal chemistry. 2021 Nov 11;64(21):16132-16146.
