4 Results for "

PCC16

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "PCC16" in MCE Product Catalog:

Cat. No.: HY-169232
Target:  

PROTACs PD-1/PD-L1

Research Areas:  

Cancer

PCC16 chloride is a dual PROTAC degrader targeting DHHC3 and PD-L1, with a DC50 of 0.103 μM for PD-L1 degradation. PCC16 chloride induces DHHC3 degradation via the ubiquitin-proteasome pathway by recruiting the CRBN E3 ubiquitin ligase (E3 ubiquitin ligase). By targeting DHHC3-which is essential for PD-L1 palmitoylation and membrane stability-PCC16 chloride reduces PD-L1 levels, decreases PD-L1 membrane retention time, and impairs its immunosuppressive function. PCC16 chloride enhances anti-tumor immunity by disrupting PD-L1-mediated immunosuppression. PCC16 chloride can be used in the research of immune checkpoint blockade-resistant cancers .
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Cat. No.: HY-169235
Research Areas:  

Cancer

DHHC3 degrader 1 is a PROTAC target protein ligand that is used to synthesize PCC16 chloride (HY-169232) .
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Cat. No.: HY-169236
CAS No.: 947504-71-4
Target:  

PROTAC Linkers

Research Areas:  

Cancer

COOH-C-PEG2-NHCO-C2-COOH is a PROTAC linker that is used to synthesize PCC16 chloride (HY-169232) .
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Cat. No.: HY-169237
Research Areas:  

Cancer

Pomalidomide-C2-CONH-PEG2-C-COOH is a conjugate of E3 ligase ligand and linker and can be used in the synthesis of PCC16 chloride (HY-169232) .
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