1 Result for "

PF03475952

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "PF03475952" in MCE Product Catalog:

Cat. No.: HY-P992437

Target:  

CD44 Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

PF-03475952 is a fully human IgG2 monoclonal antibody targeting CD44. PF-03475952 binds an epitope in CD44’s constant exons, blocks CD44-hyaluronic acid interaction, reduces cell surface CD44, and does not cross-react with rodent CD44 or LYVE-1. PF-03475952 induces cancer cell apoptosis, inhibits LPS (HY-D1056)-induced leukocyte cytokine release and cancer metastasis, and reduces CD44 expression on circulating CD3+ lymphocytes in cynomolgus monkeys. PF-03475952 can be used for the research of rheumatoid arthritis and hepatocellular carcinoma .
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