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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
46 Results for "
PKB/AKT
" in MedChemExpress (MCE) Product Catalog:
Products (46)
46 Results for "PKB/AKT" in MCE Product Catalog:
7
7 Publications Verification
Synonyms: 2’,3,4,4’-tetrahydroxy Chalcone
4
4
4 Cited Publications
Cat. No.: HY-P80276
Synonyms: AKT 1 antibody; AKT antibody; AKT1 antibody; AKT1_HUMAN antibody; MGC99656 antibody; PKB antibody; PKB-ALPHA antibody; PRKBA antibody; Protein Kinase B Alpha antibody; Protein kinase B antibody; Proto-oncogene c-AKT antibody; RAC Alpha antibody; RAC antibody; RAC-alpha serine/threonine-protein kinase antibody; RAC-PK-alpha antibody;
3
3 Cited Publications
Cat. No.: HY-N1401
CAS No.: 112246-15-8
2
1
1 Cited Publications
API-1 is a potent selective Akt/PKB inhibitor that reduces the level of phosphorylated Akt (IC50 = 0.8 μM). API-1 binds to the PH domain and inhibits Akt membrane translocation. API-1 induces c-FLIP degradation. API-1 reduces cell proliferation and induces apoptosis. API-1 decreases tumor growth in mouse xenograft model .
1
Target:
Research Areas:
Hematein is a oxidation product of hematoxylin acted as a dye . Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells .
1
1 Cited Publications
Cat. No.: HY-P702631
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: AKT1; Protein Kinase B; AKT Serine/Threonine Kinase 1; PKB Alpha; RAC; V-AKT Murine Thymoma Viral Oncogene-Like Protein 1 Isoform 2; PKB; V-AKT Murine Thymoma Viral Oncogene-Like Protein 1; RAC-Alpha Serine/Threonine-Protein Kinase; Non-Specific Serine/Threonine Protein Kinase; RAC-PK-Alpha; AKT1m Transcript Variant 3; RAC-Alpha; AKT1m Transcript Variant 4; PRKBA; AKT1m Transcript Variant 2; AKT; AKT1m Transcript Variant 1; V-AKT Murine Thymoma Viral Oncogene Homolog 1; Rac Protein Kinase Alpha; Serine-Threonine Protein Kinase; PKB-ALPHA; Protein Kinase B Alpha; AKT1m; Proto-Oncogene C-AKT
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P74420
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: AKT2; Non-Specific Serine/Threonine Protein Kinase; AKT Serine/Threonine Kinase 2; Murine Thymoma Viral (V-AKT) Homolog-2; V-AKT Murine Thymoma Viral Oncogene Homolog 2; Rac Protein Kinase Beta; RAC-Beta Serine/Threonine-Protein Kinase; RAC Protein Kinase Beta; Protein Kinase B Beta; AKT2 Protein; Protein Kinase AKT-2; RAC-BETA; RAC-PK-Beta; PKBBETA; PKB Beta; HIHGHH; PKBB; PRKBB; Putative V-AKT Murine Thymoma Viral Oncoprotein 2; PKBβ
Species:
Human
Source:
Sf9 insect cells
PS210 is a potent and selective PDK1 activator with a Kd of 3 μM and targets the PIF-binding pocket of PDK1. PS210 is inactive against other protein kinases, including PDK1 downstream signaling components such as S6K, PKB/Akt or GSK3. In cells, the prodrug of PS210 (PS423) acts as a substrate-selective inhibitor of PDK1, inhibiting the phosphorylation and activation of S6K .
Research Areas:
CAY10404 is a potent and selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 1 nM and a selectivity index (SI; COX-1 IC50/COX-2 IC50) of >500000. CAY10404 is a potent PKB/Akt and MAPK signaling pathways inhibitor and induces apoptosis in non-small cell lung cancer (NSCLC) cells. CAY10404, a diarylisoxazole, has good analgesic, anti-inflammatory, and anti-cancer activities .
Synonyms: AKT protein kinase inhibitor
PF-AKT400 is a broadly selective, potent, ATP-competitive Akt inhibitor, displays 900-fold greater selectivity for PKBα (IC50=0.5 nM) than PKA (IC50=450 nM).
Research Areas:
F16 is a mitochondrial permeability transition pore (PTP) modulator with an EC50 of 30 μM in mice. F16 promotes PTP opening, accumulates in cancer cell mitochondria, and induces mitochondrial depolarization, swelling, cristae disruption, outer membrane rupture, ATP depletion, reactive oxygen species (ROS) production, cytochrome c release and mitochondrial uncoupling. F16 induces cell cycle arrest at the G1 (occasionally G2) phase, reduces the phosphotyrosine content of Neu, as well as the levels of phosphorylated PKB/Akt and phosphorylated MAP kinase, downregulates the protein expression levels of Neu and PKB, triggers apoptosis in cells with moderate Bcl-2 expression, and induces necrosis in cells with overexpressed Bcl-2. F16 can be used in research related to breast cancer and gastric cancer .
Cat. No.: HY-N15314
CAS No.: 212115-96-3
Category:
Cat. No.: HY-175042
Synonyms: Ins(1,3,4,5,6)P5 ammonium salt; 1,3,4,5,6-IP5 ammonium salt
D-myo-Inositol-1,3,4,5,6-pentaphosphate (ammonium salt) (Ins(1,3,4,5,6)P5 (ammonium salt)) is an isomer of inositol phosphate that acts as a small and soluble second messenger in the transmission of cellular signals. D-myo-Inositol-1,3,4,5,6-pentaphosphate (ammonium salt) can bind to the PH domain of Grp1 with a Kd of 590 nM. D-myo-Inositol-1,3,4,5,6-pentaphosphate (ammonium salt) can inhibit the phosphorylation and kinase activity of Akt/PKB, inducing apoptosis in ovarian, lung, and breast cancer cells. D-myo-Inositol-1,3,4,5,6-pentaphosphate (ammonium salt) exhibits antiangiogenic activity in vitro and blocks capillary tube formation of HUVEC. D-myo-Inositol-1,3,4,5,6-pentaphosphate (ammonium salt) exerts antitumor effects against cancer xenografts in nude mice .
Cat. No.: HY-171777
CAS No.: 202867-33-2
Synonyms: ErPC3; Erucylphosphohomocholine
Erufosine is an inhibitor of PI3K/Akt and Ras/Raf/MAPK signaling pathways. Erufosine inhibits the activity of breast cancer cell lines MCF-7 and MDA-MB 231 (IC50: 40.95/40.8 μM). Erufosine reduces the phosphorylation of PI3K (p85), Akt (PKB), and cRaf. Erufosine can be used in the study of breast cancer and myeloid leukemia .
Category:
other families Flavonoids Chalcones Phenols Polyphenols Plants
Cat. No.: HY-144059
CAS No.: 2709045-53-2
AKT-IN-9 is a potent inhibitor of AKT. Protein kinase B (PKB, also known as AKT) is central to PI3K/AKT/mTOR signaling in cells, and its function is important for cell growth, survival, differentiation and metabolism. AKT-IN-9 has the potential for the research of breast and prostate cancer (extracted from patent WO2021185238A1, compound 1) .
Cat. No.: HY-144060
CAS No.: 2709045-56-5
AKT-IN-10 is a potent inhibitor of AKT. Protein kinase B (PKB, also known as AKT) is central to PI3K/AKT/mTOR signaling in cells, and its function is important for cell growth, survival, differentiation and metabolism. AKT-IN-10 has the potential for the research of breast and prostate cancer (extracted from patent WO2021185238A1, compound 4) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
