475-25-2
475-25-2
Chemical Structure
Hematein
- CAS No.: 475-25-2
- Formula:C16H12O6
- Molecular Weight:300.26
IUPAC Name: 3,4,6a,10-tetrahydroxy-6a,7-dihydroindeno[2,1-c]chromen-9(6H)-one
InChIKey: HLUCICHZHWJHLL-UHFFFAOYSA-N
SMILES: O=C1C=C2CC3(C(C4=CC=C(C(O)=C4OC3)O)=C2C=C1O)O
Biological Activity: Hematein is a oxidation product of hematoxylin acted as a dye[1]. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Hematein | 59.09% | Hematein is a oxidation product of hematoxylin acted as a dye. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
(±)-Dehydroaltenusin | (±)-Dehydroaltenusin, an antibiotic, is a selective eukaryotic DNA polymerase α (pol α) inhibitor with an IC50 of 0.68 μM. (±)-Dehydroaltenusin can be isolated from fungus Alternaria tenuis. (±)-Dehydroaltenusin competitively inhibits the DNA template primer (Ki: 0.23 μM) and non-competitively suppresses the 2'-deoxyribonucleoside 5'-triphosphate substrate (Ki: 0.18 μM). (±)-Dehydroaltenusin induces the cancer cell S-phase cycle arrest and apoptosis. (±)-Dehydroaltenusin can be used for cancers like human adenocarcinoma research. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Kigelinone | Kigelinone is a natural product. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Miaosporone A | Miaosporone A, an angucyclic quinone, exhibits antimalarial activity against Plasmodium falciparum K1 and antibacterial activity against Mycobacterium tuberculosis with respective IC50 values of 2.5 and 2.4 μM and displays cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Elmycin B | Elmycin B is a biochemical assay reagent. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Brazilein | 99.9% | Brazilein is a compound with anti-inflammatory and neuroprotective activities, with an IC50 of 500 μM against guinea pig Na+,K+-ATPase. Brazilein reduces iNOS mRNA expression, thereby inhibiting nitric oxide production in immune cells. Brazilein suppresses inflammatory responses by reducing the mRNA expression of TNF-α and IL-6, but has no effect on IL-1β expression. Brazilein reduces the cerebral infarction volume and improves the neurological function scores of rats with cerebral ischemia-reperfusion injury. Brazilein induces apoptosis of splenic lymphocytes in mice. Brazilein inhibits humoral immune responses in mice, and causes thymus and spleen atrophy as well as body weight loss in mice. Brazilein also possesses antimalarial and antibacterial activities. Brazilein is also a red dye. Brazilein can be used in studies related to the infection, nervous system, cardiovascular system and inflammatory diseases. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Elmycin D | Elmycin D is an antibiotic, which can be isolated from Streptomyces cellulosae ssp. griseoincarnatus. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Ochracenomicin A | Ochracenomicin A has a strong effect against Gram-positive bacteria (including MRSA strain), and also against Gram-negative bacteria and candida albicans. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Sakyomicin D | Sakyomicin D is a Benzoquinone antibiotic. Sakyomicin D has activity against Gram-positive bacteria. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Sakyomicin B | Sakyomicin B is a Benzoquinone antibiotic found in the strain of Nocardia sp. M-53. Sakyomicin B has activity against Gram-positive bacteria and mycobacteria. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Juncuenin D | Juncuenin D induces caspase-3-mediated cytotoxicity in HT22 cells. Juncuenin D also has anti-bacterial activity against MRSA strains. Juncuenin D can be isolated from J. effusus. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
