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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
PPID
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "PPID" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P71224
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Peptidyl-Prolyl Cis-Trans Isomerase D; PPIase D; 40 kDa Peptidyl-Prolyl Cis-Trans Isomerase; Cyclophilin-40; CYP-40; Cyclophilin-Related Protein; Rotamase D; PPID; CYP40; CYPD
Cat. No.: HY-RS10949
Target:
Research Areas:
PPID Human Pre-designed siRNA Set A contains three designed siRNAs for PPID gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS25864
Target:
Research Areas:
Ppid Rat Pre-designed siRNA Set A contains three designed siRNAs for Ppid gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS19372
Target:
Research Areas:
Ppid Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ppid gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P71224A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Peptidyl-Prolyl Cis-Trans Isomerase D; PPIase D; 40 kDa Peptidyl-Prolyl Cis-Trans Isomerase; Cyclophilin-40; CYP-40; Cyclophilin-Related Protein; Rotamase D; PPID; CYP40; CYPD
Cat. No.: HY-181062
VWK147 is a second-generation HSP90 C-terminal domain (CTD) inhibitor. VWK147 targets the CTD dimerization interface, prevents HSP90 CTD dimerization, disrupts co-chaperone PPID binding to HSP90 CTD, and inhibits HSP90 chaperone function dependent on dimerization. VWK147 reduces protein levels of HSP90 client proteins ULK1, RIPK1, and CDK4 without inducing a heat shock response. VWK147 induces cell death, including apoptosis, in Cisplatin (HY-17394)-sensitive and -resistant urothelial carcinoma cells. VWK147 induces LC3-II accumulation, inhibits autophagosome-lysosome fusion to block canonical autophagy, and induces non-canonical LC3 lipidation independent of ULK1 and PIK3C3 complexes. VWK147 can be used for the research of urothelial carcinoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
