1 Result for "

Pycnidione

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Pycnidione" in MCE Product Catalog:

Pycnidione
Pycnidione
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Cat. No.: HY-N11418
CAS No.: 149064-34-6
Category:  

Other Monoterpenes Microorganisms Terpenoids

Target:  

MMP Caspase Survivin PAI-1 Topoisomerase HIF/HIF Prolyl-Hydroxylase Apoptosis Reactive Oxygen Species (ROS)

Pycnidione is a natural small-molecule compound isolated from fungi. Pycnidione inhibits stromelysin/MMP3, targets cyclin D1/E, induces G1 phase arrest, modulates survivin, affects caspase-8/3, targets PAI-1, inhibits topoisomerases, and induces HIF-1α accumulation/nuclear translocation and DNA binding/reporter gene transactivation and erythropoietin expression. Pycnidione induces apoptosis, reactive oxygen species (ROS) generation, and mitochondrial membrane potential collapse. Pycnidione can be used for research on lung cancer .
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