1 Result for "

RTx-152

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "RTx-152" in MCE Product Catalog:

Cat. No.: HY-161431
CAS No.: 3035072-48-8
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

RTx-152 traps Polθ on DNA and is an allosteric Polθ-pol inhibitor (IC50: 6.2 nM). RTx-152 selectively kills HR-deficient cancer cells, and suppresses PARP inhibitor resistance in multiple genetic backgrounds, including homologous recombination (HR)-proficient cells. RTx-152 selectively kills BRCA2-null cells .
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