2 Results for "

SAH-SOS1A

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "SAH-SOS1A" in MCE Product Catalog:

Art. -Nr.: HY-P2265A
CAS. Nr.: 2896737-31-6
Target:  

SOS1 Ras

Forschungsgebiete:  

Cancer

SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC50=106-175 nM). SAH-SOS1A TFA directly and independently blocks nucleotide association. SAH-SOS1A TFA impairs KRAS-driven cancer cell viability and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS [1].
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Art. -Nr.: HY-P2265
CAS. Nr.: 1652561-87-9
Target:  

SOS1 Ras

Forschungsgebiete:  

Cancer

SAH-SOS1A is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC50=106-175 nM), directly and independently blocks nucleotide association, impairs KRAS-driven cancer cell viability, and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS [1].
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