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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
SARM1 TIR domain
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "SARM1 TIR domain" in MCE Product Catalog:
Cat. No.: HY-P702882
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SARM1; Sterile Alpha And Armadillo Repeat Protein; Sterile Alpha And TIR Motif Containing 1; SAM domain-Containing Protein 2; SAMD2; TIR-1 Homolog; SARM; NADase SARM1; Sterile Alpha And TIR Motif-Containing Protein 1; MyD88-5; NADP(+) Hydrolase SARM1; HSA
Species:
Human
Source:
HEK293
Cat. No.: HY-P705957
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SARM1; Sterile Alpha And Armadillo Repeat Protein; Sterile Alpha And TIR Motif Containing 1; SAM domain-Containing Protein 2; SAMD2; TIR-1 Homolog; SARM; NADase SARM1; Sterile Alpha And TIR Motif-Containing Protein 1; MyD88-5; NADP(+) Hydrolase SARM1; HSA
Species:
Human
Source:
HEK293
Cat. No.: HY-182940
Target:
Research Areas:
SARM1-IN-10 is an orally active SARM1 inhibitor with a pIC50 of 7.1 and a pKd of 8.3. As a base-exchange inhibitor, SARM1-IN-10 forms a NAD + adduct at the active site of the TIR domain of SARM1, blocks enzymatic function, and induces a unique rotameric state of W662 at the catalytic site of SARM1. SARM1-IN-10 acts as a paradoxical neurodegeneration inducer at low doses and an inhibitor at high doses, and it can exacerbate or protect against SARM1-mediated neurodegeneration depending on concentration. SARM1-IN-10 can be used in studies of peripheral neurodegeneration .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
