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SARS-CoV-2 Mpro inhibitor

" in MedChemExpress (MCE) Product Catalog:

標的別:	SARS-CoV (114) Amyloid-β (1) Antibiotic (1) Apoptosis (1) Bacterial (1) Beta-secretase (1) Cathepsin (7) Ceramidase (2) COX (2) Cytochrome P450 (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (2) Drug Intermediate (1) Environmental Pollutants (1) FAAH (2) Fungal (1) Glutathione Peroxidase (2) HCV (2) HCV Protease (2) Influenza Virus (1) Isotope-Labeled Compounds (1) NADPH Oxidase (1) Nucleoside Antimetabolite/Analog (2) PROTACs (3) Reactive Oxygen Species (ROS) (1) Reference Standards (5) Ser/Thr Protease (1) Virus Protease (50)
研究分野別:	Cancer (5) Infection (113) Inflammation/Immunology (13) Neurological Disease (2)

標的別:

SARS-CoV (114)

Amyloid-β (1)

Antibiotic (1)

Apoptosis (1)

Bacterial (1)

Beta-secretase (1)

Cathepsin (7)

Ceramidase (2)

COX (2)

Cytochrome P450 (1)

DNA Alkylator/Crosslinker (1)

DNA/RNA Synthesis (2)

Drug Intermediate (1)

Environmental Pollutants (1)

FAAH (2)

Fungal (1)

Glutathione Peroxidase (2)

HCV (2)

HCV Protease (2)

Influenza Virus (1)

Isotope-Labeled Compounds (1)

NADPH Oxidase (1)

Nucleoside Antimetabolite/Analog (2)

PROTACs (3)

Reactive Oxygen Species (ROS) (1)

Reference Standards (5)

Ser/Thr Protease (1)

Virus Protease (50)

研究分野別:

Cancer (5)

Infection (113)

Inflammation/Immunology (13)

Neurological Disease (2)

116

阻害剤およびアゴニスト

ペプチド

天然物

同位体標識化合物

Targets Recommended: SARS-CoV

製品番号	製品名	Target	研究分野	構造式

HY-136149

Mpro inhibitor N3	SARS-CoV Virus Protease	Infection
Mpro inhibitor N3 is a potent **SARS-CoV-2 MPro** inhibitor with an EC₅₀ value of 16.77 µM. Mpro inhibitor N3 shows antiviral activities against HCoV-229E, FIPV, IBV and MHV-A59 .

HY-126085

(±)-Alliin 3 Publications Verification (±)-L-Alliin	SARS-CoV	Infection
(±)-Alliin is the main active component of garlic. (±)-Alliin is a putative inhibitor of the main protease of **SARS-CoV-2 (M_pro)** .

HY-138078

Lufotrelvir 2 Publications Verification PF-07304814	SARS-CoV	Infection
Lufotrelvir (PF-07304814), a phosphate proagent of PF-00835231, acts as a potent 3CLpro protease (Mpro) inhibitor with SARS-CoV-2 antiviral activity. Lufotrelvir binds and inhibits SARS-CoV-2 3CLpro activity with a Ki of 174nM. Lufotrelvir is promising single antiviral agent and also can be used for the research of combination with other antivirals that target other critical stages of the coronavirus life cycle.

HY-151482

SARS-CoV-2 Mpro-IN-2	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-2 (compound GC-14) is a selective, low cytotoxic and non-covalent M ^pro inhibitor (IC₅₀=0.40 μM) with good anti-SARS-CoV-2 activity (EC₅₀=1.1 μM). SARS-CoV-2 Mpro-IN-2 can be used in COVID-19 studies .

HY-176264

DNDI-6510	SARS-CoV Virus Protease Cytochrome P450	Infection
DNDI-6510 (Compound (S)-x38) is a non-covalent **SARS-CoV-2 MPro** inhibitor with a IC₅₀ of 0.04 μM. DNDI-6510 has a potent antiviral activity across SARS-CoV-2 and its variants as well as a weak efficacy to SARS-CoV-1. DNDI-6510 significantly improves drug exposure in metabolically humanized mice model (8HUM) .

HY-153533A

GRL-1720 TFA	SARS-CoV	Infection
GRL-1720 TFA is a potent inhibitor of SARS-CoV-2 Mpro with an EC50 value of 15 μM. GRL-1720 TFA shows anti-SARS-CoV2 activity .

HY-N12697A

Polycarpine hydrochloride	SARS-CoV Virus Protease Influenza Virus Fungal	Infection
Polycarpine hydrochloride (1a) is a broad-spectrum *Mpro* inhibitor (IC₅₀ = 30 nM) that can be isolated from the Polycarpa aurata and also serves as an anti-coronaviral agent. Polycarpine hydrochloride possesses antiviral and antifungal activities, with IC₅₀ values of 30.0 nM and 0.12 μM against **SARS-CoV-2 Mpro** and PEDV Mpro, respectively .

HY-152108

SARS-CoV-2 Mpro-IN-6	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-6 is a covalent, irreversible and selective SARS-CoV-2 M ^pro inhibitor with an IC₅₀ of 0.18 μM. SARS-CoV-2 Mpro-IN-6 does not inhibit human cathepsins B, F, K, and L, and caspase 3 .

HY-170309

NZ-804	SARS-CoV Virus Protease	Infection
NZ-804 is an orally active inhibitor for **SARS-CoV-2 main protease Mpro with an IC₅₀** of 8.9 nM. NZ-804 inhibits the SARS-CoV-2 replication in HeLa-hACE2 cell with an EC₅₀ of 14 nM. NZ-804 exhibits board-spectrum antiviral activity aganst multiple CoVs. NZ-804 diminishes virus replication in mouse and hamster model .

HY-124439

Setomimycin	Antibiotic Bacterial SARS-CoV	Infection Cancer
Setomimycin is a potent antibiotic. Setomimycin inhibits the SARS-CoV-2 Mpro enzyme with an IC₅₀ value of 12.02 µM. Setomimycin shows anti-inflammatory and antioxidant properties. Setomimycin shows antiproliferative and antitumor activity .

HY-178480

SARS-CoV-2 Mpro-IN-49	SARS-CoV Virus Protease	Infection
SARS-CoV-2 Mpro-IN-49 (Compound 22e) is a potent SARS-CoV-2 main protease (M ^pro) inhibitor (IC₅₀=0.087 μM). SARS-CoV-2 Mpro-IN-49 is promising for research of SARS-CoV-2 and coronavirus .

HY-135860

SARS-CoV-2-IN-1	Virus Protease SARS-CoV	Infection
SARS-CoV-2-IN-1 is a potent *Mpro* inhibitor. SARS-CoV-2-IN-1 inhibits the purified recombinant SARS-CoV-2 Mpro, SARS-CoV Mpro and MERS-CoV Mpro with IC₅₀s of 0.67, 0.90 and 0.58 μM, respectively .

HY-149606

TKB245	SARS-CoV	Infection
TKB245 is a highly potent **SARS-CoV-2 Mpro** inhibitor that effectively blocks SARS-CoV-2 replication in VeroE6 cells .

HY-176232

BBH-4	SARS-CoV	Infection
BBH-4 is a *SARS-CoV-2* major protease (MPro) inhibitor. BBH-4 can be used in SARS-CoV-2 infection research .

HY-136149A

Mpro inhibitor N3 hemihydrate	SARS-CoV Virus Protease	Infection
Mpro inhibitor N3 hemihydrate is a potent inhibitor of **SARS-CoV-2 Mpro** with an EC₅₀ of 16.77 μM for SARS-CoV-2. Mpro inhibitor N3 hemihydrate specifically inhibits Mpro from multiple coronaviruses, including SARS-CoV and MERS-CoV. Mpro inhibitor N3 hemihydrate displays inhibition against HCoV-229E, FIPV, and MHV-A59 with individual IC₅₀ of 4.0 μM, 8.8 μM, and 2.7 μM, respectively .

HY-158763

MPI8 TG0205221	SARS-CoV Cathepsin Virus Protease	Infection
MPI8 (TG0205221) is an inhibitor of the major protease of *SARS-CoV-2* (MPro) with high antiviral activity. MPI8 exerts its antiviral effect by dual and selective inhibition of SARS-CoV-2 *MPro* and host cell cysteine protease L (cathepsin L). MPI8 can be used in clinical studies of COVID-19 .

HY-156734

D-4-77	SARS-CoV Virus Protease	Infection
D-4-77 is a potent inhibitor of **SARS-CoV-2 Mpro with an IC₅₀ value of 0.95 μM. D-4-77 has antiviral active with an EC₅₀** value of 0.49 μM. D-4-77 suppresses SARS-CoV-2 Mpro -induced antagonism of the host NF-κB innate immune response .

HY-158763A

MPI8 TFA TG0205221 TFA	SARS-CoV Cathepsin Virus Protease	Infection
MPI8 (TG0205221) TFA is an inhibitor of the major protease of *SARS-CoV-2* (MPro) with high antiviral activity. MPI8 TFA exerts its antiviral effect by dual and selective inhibition of SARS-CoV-2 *MPro* and host cell cysteine protease L (cathepsin L). MPI8 TFA can be used in clinical studies of COVID-19 .

HY-162464

MPD2	PROTACs SARS-CoV	Infection
MPD2 is a Cereblon-binding ligand-based PROTAC that degrades *MPro, the main protease of SARS-CoV-2. MPD2 effectively reduced MPro* protein levels in 293T cells in a time-dependent manner (DC₅₀=296 nM). MPD2 exhibited potent antiviral activity against multiple SARS-CoV-2 strains and had enhanced potency against Nirmatrelvir (HY-138687) resistant strains. MPD2 provides a new direction for antiviral drug development against SARS-CoV-2 and other emerging coronavirus pathogens (Sturcture Note:(Blue: Cereblon ligand (HY-14658), Black: linker (HY-W275882)；Red: SARS-CoV-2 MPro Inhibitor MP18 (HY-158763)) .

HY-163389

Mpro/Cathepsin L-IN-1	SARS-CoV Cathepsin	Infection
Mpro/Cathepsin L-IN-1 (Compound 4d) is a SARS-CoV-2 M ^pro/hCatL inhibitor, with K_is of 5.54 μM and 0.701 μM respectively .

HY-155144

CDD-1845	SARS-CoV	Infection
CDD-1845 is a non-covalent and non-peptide potent **SARS-CoV-2 Mpro** inhibitor with a K_i of 3 nM. CDD-1845 also inhibits ΔP168, A173V, and ΔP168/A173V Mpro variants .

HY-155142

CDD-1819	SARS-CoV	Infection
CDD-1819 is a non-covalent and non-peptide potent **SARS-CoV-2 Mpro** inhibitor with a K_i of 5 nM. CDD-1819 also inhibits ΔP168, A173V, and ΔP168/A173V Mpro variants .

HY-155143

CDD-1733	SARS-CoV	Infection
CDD-1733 is a non-covalent and non-peptide potent **SARS-CoV-2 Mpro** inhibitor with a K_i of 12 nM. CDD-1733 also inhibits ΔP168, A173V, and ΔP168/A173V Mpro variants .

HY-170545

SARS-CoV-2 Mpro-IN-35	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-35 (compound 14) is a **SARS-CoV-2 Mpro** inhibitor. SARS-CoV-2 Mpro-IN-35 can be used for the research of SARS-CoV-2 virus .

HY-175712

SARS-CoV-2 Mpro-IN-47	SARS-CoV Virus Protease	Infection
SARS-CoV-2 Mpro-IN-47 is an orally active SARS-CoV-2 Mpro reversible covalent Inhibitor. SARS-CoV-2 Mpro-IN-47 shows potent antiviral activity against several clinical variants of SARS-CoV-2. SARS-CoV-2 Mpro-IN-47 can be used for the research of infection, such as SARS-CoV-2 .

HY-178772

SARS-CoV-2 Mpro-IN-50	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-50 (Compound 30) is a noncovalent **SARS-CoV-2 Mpro** inhibitor with an IC₅₀ of 14  nM. SARS-CoV-2 Mpro-IN-50 is also a pan-CoV Mpro inhibitor with IC₅₀s of 20-190 nM for SARS-CoV-1 Mpro, 229E Mpro, HKU1 Mpro, MERS Mpro, NL63 Mpro and OC43 Mpro. SARS-CoV-2 Mpro-IN-50 has significant antiviral activity against the SARS-CoV-2 omicron variant (EC₅₀: 22  nM). SARS-CoV-2 Mpro-IN-50 can be used for coronavirus infections research .

HY-173514

SARS-CoV-2 Mpro-IN-42	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-42 (compound C5) is a potent **SARS-CoV-2 Mpro** inhibitor with an IC₅₀ of 33.6 nM. SARS-CoV-2 Mpro-IN-42 can be used in the study of SARS-CoV-2 .

HY-159961

SARS-CoV-2 Mpro-IN-34	SARS-CoV Virus Protease	Infection
SARS-CoV-2 Mpro-IN-34 (Compound 26) is an inhibitor for **SARS-CoV-2 Mpro with an IC₅₀** of 6 nM. SARS-CoV-2 Mpro-IN-34 exhibits inhibitory efficacy against OC43 Mpro with an IC₅₀ of 33 nM. SARS-CoV-2 Mpro-IN-34 exhibits antiviral activity in SARS-CoV-2 infected Vero E6 cell with an EC₅₀ of 0.103 μM .

HY-158687

SARS-CoV-2 Mpro-IN-18	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-18 (compound 84) is a potent **SARS-CoV-2 Mpro** inhibitor with the IC₅₀ of 3.23 nM. SARS-CoV-2 Mpro-IN-18 can be used for study of anti-SARS-CoV-2 agent .

HY-169200

SARS-CoV-2 Mpro-IN-26	SARS-CoV	Cancer
SARS-CoV-2 Mpro-IN-26 (compund 13) is a covalent inhibitor of **SARS-CoV-2 Mpro** .

HY-173426

SARS-CoV-2 Mpro-IN-40	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-40 (compound 119) is an inhibitor of **SARS-CoV-2 Mpro, with an IC₅₀** value of 15.7 nM against Mpro Fret. SARS-CoV-2 Mpro-IN-40 exhibits low metabolic stability in human microsomes .

HY-169260

SARS-CoV-2 Mpro-IN-27	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-27 (Compound 4h) is a potent **SARS-CoV-2 Mpro** inhibitor .

HY-161777

SARS-CoV-2 Mpro-IN-23	SARS-CoV Virus Protease	Infection
SARS-CoV-2 Mpro-IN-23 (Compound 2) is an inhibitor for SARS-CoV-2 main protease (Mpro), which inhibits wildtype Mpro and mutant Mpro variants, with IC₅₀ of 0.057-0.92 μM. SARS-CoV-2 Mpro-IN-23 inhibits the post-entry viral processes of wild-type SARS-CoV-2 single-round infectious particles (SRIPs), suppresses the viral replication of Mpro wildtype and Mpro mutants with EC₅₀ of 0.02-0.52 μM .

HY-163627

SARS-CoV-2 Mpro-IN-19	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-19 (compound MPI94) is a **SARS-CoV-2 MPro** inhibitor with the IC₅₀ of 0.096 μM. SARS-CoV-2 Mpro-IN-19 can be used for study of COVID-19 .

HY-159911

SARS-CoV-2 Mpro-IN-29	SARS-CoV Virus Protease
SARS-CoV-2 Mpro-IN-29 (Compound 7) is an inhibitor of the SARS-CoV-2 main protease (Mpro) with an IC₅₀ of 310 nM and an EC₅₀ of 0.5 μM in Vero cells. SARS-CoV-2 Mpro-IN-29 binds to the active site of *Mpro, blocking the cleavage of viral polyproteins, showing significant antiviral activity and enhanced metabolic function. SARS-CoV-2* Mpro-IN-29 holds potential for research on SARS-CoV-2 antiviral agents .

HY-178435

SARS-CoV-2 Mpro-IN-48	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-48 is a potent *SARS-CoV-2* main protease inhibitor with an IC₅₀ of 21.1 nM. SARS-CoV-2 Mpro-IN-48 exhibits potent antiviral activity against the SARS-CoV-2 JN.1 variant. SARS-CoV-2 Mpro-IN-48 can be used for the research of infection, such as COVID-19 .

HY-176211

SARS-CoV-2 Mpro-IN-45	SARS-CoV Virus Protease	Infection
SARS-CoV-2 Mpro-IN-45 (compound 28f) is an orally active Mpro inhibitor with IC₅₀ values of 0.12 and 0.16 μM for HCoV-OC43 Mpro and SARS-CoV-2 Mpro, respectively. SARS-CoV-2 Mpro-IN-45 exhibits antiviral activity .

HY-168600

SARS-CoV-2 Mpro-IN-32	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-32 (Compound 1) is a selective inhibitor of SARS-CoV-2 M ^Pro with an IC₅₀ value of 230 nM. SARS-CoV-2 Mpro-IN-32 can also inhibit the replication of multiple *SARS-CoV-2* variants in vitro .

HY-158347

SARS-CoV-2 Mpro-IN-15	SARS-CoV	Infection Inflammation/Immunology
SARS-CoV-2 Mpro-IN-15 (8E) is a **SARS-CoV-2 Mpro** inhibitor, with an IC₅₀ of 0.606 µM .

HY-172960

SARS-CoV-2 Mpro-IN-44	SARS-CoV Virus Protease	Infection Inflammation/Immunology
SARS-CoV-2 Mpro-IN-44 (Compound 25) is a broad-spectrum coronavirus main protease (Mpro) inhibitor. SARS-CoV-2 Mpro-IN-44 has inhibitory activity against a variety of high-risk coronaviruses (including SARS-CoV-2 and PEDV, etc.) (IC₅₀: < 0.6 μM). SARS-CoV-2 Mpro-IN-44 achieves broad-spectrum inhibition of coronaviruses by enhancing the interaction with the conserved sites of Mpro. SARS-CoV-2 Mpro-IN-44 can be used for anti-coronavirus drug development .

HY-158422

SARS-CoV-2 Mpro-IN-16	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-16 (compound 5J) is a **SARS-CoV-2 Mpro** inhibitor, and inhibits HEK293 cells growth .

HY-163186

SARS-CoV-2 Mpro-IN-13	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-13 (compound 20j) is a covalent **SARS-CoV-2 Protease Mpro** inhibitor with an IC₅₀ value of 19.0 nM. SARS-CoV-2 Mpro-IN-13 processes antiviral activity with an EC₅₀ value of 138.1 nM .

HY-156459

SARS-CoV-2 Mpro-IN-12	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-12 (compound D026) is a **SARS-CoV-2 main protease (Mpro)** inhibitor with antiviral activities .

HY-175015

SARS-CoV-2 Mpro-IN-46	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-46 (Compound 12) is a SARS-CoV-2 main protease inhibitor with an IC₅₀ of ∼25 μM. SARS-CoV-2 Mpro-IN-46 has potent antiviral activity with low cytotoxicity against SARS-CoV-2 (IC₅₀: 7.4 μM). SARS-CoV-2 Mpro-IN-46 can be used for coronaviruses COVID-19 research .

HY-163211

SARS-CoV-2 Mpro-IN-14	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-14 (Compound 19) is an inhibitor of **SARS-CoV-2 Mpro with an IC₅₀** of 0.044 μM. SARS-CoV-2 Mpro-IN-14 exhibits water solubility, has no cytotoxicity, and can be used in the study of COVID-19 .

HY-163628

SARS-CoV-2 Mpro-IN-20	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-20 (compound MPI100) is a *SARS-CoV-2* main protease inhibitor. SARS-CoV-2 Mpro-IN-20 shows antiviral activity with the EC₅₀ of 3.4 μM .

HY-158440

SARS-CoV-2 Mpro-IN-17	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-17 (compound S5-28) is an orally active and noncovalent **SARS-CoV-2 Mpro** inhibitor with the EC₅₀ of 1.35 μM. SARS-CoV-2 Mpro-IN-17 can be used for study of COVID-19 .

HY-179102

SARS-CoV-2 Mpro-IN-51	SARS-CoV Virus Protease	Infection
SARS-CoV-2 Mpro-IN-51 (compound 4) is a **SARS-CoV-2 Mpro** inhibitor (IC₅₀ = 26 nM). SARS-CoV-2 Mpro-IN-51 has inhibitory effects on the triple mutant L50F/E166A/L167F. SARS-CoV-2 Mpro-IN-51 can be used for research on viral infections .

HY-151901

SARS-CoV-2 Mpro-IN-5	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-5 is a dual Inhibitor of Main Protease (M ^Pro) and Cathepsin L (CatL), with IC₅₀s of 1800 nM and 145 nM respectively. SARS-CoV-2 Mpro-IN-5 has antiviral activity against SARS-CoV2. SARS-CoV-2 Mpro-IN-5 blocks SARS-CoV2 replication in hACE2 expressing A549 cells with IC₅₀ value of 14.7 nM .

HY-151900

SARS-CoV-2 Mpro-IN-4	SARS-CoV Virus Protease	Infection
SARS-CoV-2 Mpro-IN-4 is a dual Inhibitor of Main Protease (M ^Pro) and Cathepsin L (CatL), with IC₅₀s of 900 nM and 60 nM respectively. SARS-CoV-2 Mpro-IN-4 has antiviral activity against SARS-CoV2. SARS-CoV-2 Mpro-IN-4 blocks SARS-CoV2 replication in hACE2 expressing A549 cells with IC₅₀ value of 8.2 nM .

製品番号	製品名	Target	研究分野

HY-P11579

TLP-3	SARS-CoV	Infection
TLP-3, Temporin L (HY-P2523) analogue, is a *SARS-CoV-2* main protease (Mpro) inhibitor with an IC₅₀ of 7.0 μM. TLP-3 inhibits protease activity through stabilizing hydrogen bonding and hydrophobic interactions with key enzyme residues. TLP-3 can be used for the research of ARS-CoV‑2 infection .

製品番号	製品名	Category	Target	構造式

HY-N1739

Tectoquinone 1 Publications Verification 2-Methylanthraquinone	Quinones Structural Classification Clausena heptaphylla (Roxb.) Wight & Arn. Anthraquinones Rutaceae Plants Source Classification	Environmental Pollutants DNA Alkylator/Crosslinker SARS-CoV Virus Protease
Tectoquinone (2-Methylanthraquinone) is an inhibitor for SARS CoV-2 major protease (SARS CoV-2 Mpro). Tectoquinone exhibits anti-termite and antiviral activities .

HY-126085

(±)-Alliin 3 Publications Verification (±)-L-Alliin	Infection Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Plants Disease Research Fields A．Sativam L. var．Viviparum Regel Source Classification	SARS-CoV
(±)-Alliin is the main active component of garlic. (±)-Alliin is a putative inhibitor of the main protease of **SARS-CoV-2 (M_pro)** .

HY-N8671

Withanoside V	Structural Classification Withania somnifera Solanaceae Plants Steroids Source Classification	Amyloid-β Apoptosis Reactive Oxygen Species (ROS) SARS-CoV
Withanoside V is a blood-brain barrier-permeable withanolide derivative . Withanoside V binds strongly to Sudlow I (domain IIA) of human serum albumin (HSA) to form a stable complex and alter the secondary structure of albumin, thereby increasing helix content and reducing β-sheet and random coil. Withanoside V binds to Aβ (1-42) to block the interaction between monomers and subsequent aggregation. Withanoside V inhibits the viability of neuroblastoma cells, reduces the number of apoptotic cells induced by Aβ (1-42), and decreases ROS production. Withanoside V inhibits SARS-CoV-2 *M_pro*. Withanoside V can be used for research on Alzheimer's disease and coronavirus disease 2019 .

HY-N12697A

Polycarpine hydrochloride	Alkaloids Animals Other Alkaloids Source Classification	SARS-CoV Virus Protease Influenza Virus Fungal
Polycarpine hydrochloride (1a) is a broad-spectrum *Mpro* inhibitor (IC₅₀ = 30 nM) that can be isolated from the Polycarpa aurata and also serves as an anti-coronaviral agent. Polycarpine hydrochloride possesses antiviral and antifungal activities, with IC₅₀ values of 30.0 nM and 0.12 μM against **SARS-CoV-2 Mpro** and PEDV Mpro, respectively .

HY-18234AR

Leupeptin hemisulfate (Standard)	Structural Classification 天然物 Microorganisms Source Classification	Reference Standards Cathepsin Ser/Thr Protease Virus Protease
Leupeptin (hemisulfate) (Standard) is the analytical standard of Leupeptin (hemisulfate). This product is intended for research and analytical applications. Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits Mpro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity[1][2][3].

HY-N1739R

Tectoquinone (Standard) 2-Methylanthraquinone (Standard)	Quinones Structural Classification Clausena heptaphylla (Roxb.) Wight & Arn. Anthraquinones Rutaceae Plants Source Classification	Reference Standards SARS-CoV Virus Protease
Tectoquinone (Standard) is the analytical standard of Tectoquinone. This product is intended for research and analytical applications. Tectoquinone (2-Methylanthraquinone) is an inhibitor for SARS CoV-2 major protease (SARS CoV-2 Mpro). Tectoquinone exhibits anti-termite and antiviral activities .

HY-N11896A

10-Hydroxyaloin A	天然物 Liliaceae Aloe vera (L.) Burm. f. Plants Source Classification	SARS-CoV
10-10-Hydroxyaloin A is potent *SARS-CoV-2* inhibitor. 10-Hydroxyaloin A exhibits significant efficacy to bind SARS-Cov-2 M_pro active site .

HY-N144101

SARS-CoV MPro-IN-2	Infection Quinones Classification of Application Fields Plants Lithospermum canescens Lehm. Naphthalene Quinones Disease Research Fields Boraginaceae Source Classification	SARS-CoV
SARS-CoV MPro-IN-2 (compound 15) is a potent inhibitor of SARS-CoV-2 M ^pro with an IC₅₀ value of 72.07 nM. The main protease (M ^pro) of the virus as the major enzyme processing viral polyproteins contributes to the replication and transcription of SARS-CoV-2 in host cells, and has been characterized as an attractive target in agent discovery. SARS-CoV MPro-IN-2 has the potential for the research of COVID-19 .

HY-126085R

(±)-Alliin (Standard) (±)-L-Alliin (Standard)	Liliaceae Ketones, Aldehydes, Acids Plants A．Sativam L. var．Viviparum Regel Source Classification	Reference Standards SARS-CoV
(±)-Alliin (Standard) is the analytical standard of (±)-Alliin. This product is intended for research and analytical applications. (±)-Alliin is the main active component of garlic. (±)-Alliin is a putative inhibitor of the main protease of SARS-CoV-2 (Mpro) .

製品番号	製品名	構造式

HY-10241S

Simeprevir-13C,d3

Simeprevir- ¹³C,d₃ is the ¹³C- and deuterium labeled Simeprevir. Simeprevir is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a K_i of 0.36 nM. Simeprevir inhibits HCV replication with an EC₅₀ of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses .

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