1. Anti-infection
  2. Virus Protease
    SARS-CoV
  3. SARS-CoV-2-IN-1

SARS-CoV-2-IN-1 

Cat. No.: HY-135860
Handling Instructions

SARS-CoV-2-IN-1 is a potent Mpro inhibitor. SARS-CoV-2-IN-1 inhibits the purified recombinant SARS-CoV-2 Mpro, SARS-CoV Mpro and MERS-CoV Mpro with IC50s of 0.67, 0.90 and 0.58 μM, respectively.

For research use only. We do not sell to patients.

SARS-CoV-2-IN-1 Chemical Structure

SARS-CoV-2-IN-1 Chemical Structure

CAS No. : 2412965-59-2

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Description

SARS-CoV-2-IN-1 is a potent Mpro inhibitor. SARS-CoV-2-IN-1 inhibits the purified recombinant SARS-CoV-2 Mpro, SARS-CoV Mpro and MERS-CoV Mpro with IC50s of 0.67, 0.90 and 0.58 μM, respectively[1].

In Vitro

In a SARS-CoV replicon, SARS-CoV-2-IN-1 (compound 13b) inhibits RNA replication with an EC50 of 1.75 μM. In human Calu3 cells infected with the novel coronavirus, SARS-CoV-2, SARS-CoV-2-IN1 shows an EC50 of 4-5 μM[1].

In Vivo

SARS-CoV-2-IN-1 (3 mg/kg; subcutaneous) shows the Cmax is 126.2 ng/mL. The mean residence time for SARS-CoV-2-IN-1 is extended to 2.7 hours and the plasma half-life in CD-1 mice is 1.8 hour[1].

Molecular Weight

593.67

Formula

C₃₁H₃₉N₅O₇

CAS No.

2412965-59-2

SMILES

O=C1C(NC(OC(C)(C)C)=O)=CC=CN1[[email protected]@H](CC2CC2)C(N[[email protected]@H](C[[email protected]@H]3CCNC3=O)C(C(NCC4=CC=CC=C4)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SARS-CoV-2-IN-1Virus ProteaseSARS-CoVSARS coronaviruscoronavirusinfectionCalu3cellsMproRNAreplicationInhibitorinhibitorinhibit

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SARS-CoV-2-IN-1
Cat. No.:
HY-135860
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