SARS-CoV-2-IN-1
SARS-CoV-2-IN-1 is a potent Mpro inhibitor. SARS-CoV-2-IN-1 inhibits the purified recombinant SARS-CoV-2 Mpro, SARS-CoV Mpro and MERS-CoV Mpro with IC50s of 0.67, 0.90 and 0.58 μM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 2412965-59-2
- Formula: C31H39N5O7
- Molecular Weight:593.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
>100 μM
Compound: 13; (S,S,S)-M(pro) 13b-K
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Cytotoxicity against human A549 cells expressing ACE2 and TMPRSS2 assessed reduction in cell viability
Cytotoxicity against human A549 cells expressing ACE2 and TMPRSS2 assessed reduction in cell viability
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[PMID: 36179320] |
| Vero C1008 | CC50 |
>100 μM
Compound: 13; (S,S,S)-M(pro) 13b-K
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Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability
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[PMID: 36179320] |
| Vero C1008 | EC50 |
17.1 nM
Compound: 13b
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Antiviral activity against SARS-CoV-2 variant Omicron BA.2 infected in African green monkey Vero E6 cells assessed as reduction in virus-induced cytopathic effect
Antiviral activity against SARS-CoV-2 variant Omicron BA.2 infected in African green monkey Vero E6 cells assessed as reduction in virus-induced cytopathic effect
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[PMID: 37229831] |
In a SARS-CoV replicon, SARS-CoV-2-IN-1 (compound 13b) inhibits RNA replication with an EC50 of 1.75 μM. In human Calu3 cells infected with the novel coronavirus, SARS-CoV-2, SARS-CoV-2-IN1 shows an EC50 of 4-5 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2412965-59-2
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Molecular Weight 593.67
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Formula C31H39N5O7
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SMILES
O=C1C(NC(OC(C)(C)C)=O)=CC=CN1[C@@H](CC2CC2)C(N[C@@H](C[C@@H]3CCNC3=O)C(C(NCC4=CC=CC=C4)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SARS-CoV-2-IN-1 Related Classifications
HY-135860 Related Classifications
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