SARS-CoV-2-IN-1
SARS-CoV-2-IN-1 is a potent Mpro inhibitor. SARS-CoV-2-IN-1 inhibits the purified recombinant SARS-CoV-2 Mpro, SARS-CoV Mpro and MERS-CoV Mpro with IC50s of 0.67, 0.90 and 0.58 μM, respectively.
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- CAS No.: 2412965-59-2
- Formule: C31H39N5O7
- Masse moléculaire:593.67
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
>100 μM
Compound: 13; (S,S,S)-M(pro) 13b-K
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Cytotoxicity against human A549 cells expressing ACE2 and TMPRSS2 assessed reduction in cell viability
Cytotoxicity against human A549 cells expressing ACE2 and TMPRSS2 assessed reduction in cell viability
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[PMID: 36179320] |
| Vero C1008 | CC50 |
>100 μM
Compound: 13; (S,S,S)-M(pro) 13b-K
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Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability
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[PMID: 36179320] |
| Vero C1008 | EC50 |
17.1 nM
Compound: 13b
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Antiviral activity against SARS-CoV-2 variant Omicron BA.2 infected in African green monkey Vero E6 cells assessed as reduction in virus-induced cytopathic effect
Antiviral activity against SARS-CoV-2 variant Omicron BA.2 infected in African green monkey Vero E6 cells assessed as reduction in virus-induced cytopathic effect
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[PMID: 37229831] |
In Vitro
In a SARS-CoV replicon, SARS-CoV-2-IN-1 (compound 13b) inhibits RNA replication with an EC50 of 1.75 μM. In human Calu3 cells infected with the novel coronavirus, SARS-CoV-2, SARS-CoV-2-IN1 shows an EC50 of 4-5 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2412965-59-2
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Masse moléculaire 593.67
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Formule C31H39N5O7
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SMILES
O=C1C(NC(OC(C)(C)C)=O)=CC=CN1[C@@H](CC2CC2)C(N[C@@H](C[C@@H]3CCNC3=O)C(C(NCC4=CC=CC=C4)=O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SARS-CoV-2-IN-1 Related Classifications
HY-135860 Related Classifications
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